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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 74 No. 3, 2020.

Ostalo

JOHN CUNNINGHAM VIRUS-ASSOCIATED NEPHROPATHY IN A KIDNEY TRANSPLANT RECIPIENT

MARKO BANIĆ ; Klinički bolnički centar Zagreb, Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska
MARIJANA ĆORIĆ ; Klinički bolnički centar Zagreb, Zavod za patologiju; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska
VESNA FURIĆ-ČUNKO ; Klinički bolnički centar Zagreb, 1Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
MISLAV MOKOS ; Klinički bolnički centar Zagreb, Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska
IVANA JURIĆ ; Klinički bolnički centar Zagreb, 1Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
NIKOLINA BAŠIĆ-JUKIĆ orcid id orcid.org/0000-0002-0221-2758 ; Klinički bolnički centar Zagreb, Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska

Puni tekst: engleski pdf 535 Kb

str. 245-247

preuzimanja: 337

citiraj

Sažetak

John Cunningham (JC) virus is a well-known cause of progressive multifocal encephalopathy. Only a few cases of polyomavirus-associated nephropathy due to JC virus have been reported so far. We report one such case in a kidney transplant recipient who presented with proteinuria and increased serum creatinine. Allograft biopsy revealed polyoma virus-associated nephropathy. Real-time polymerase chain reaction revealed negative result for BK and JC virus in the blood, negative for BK virus and positive for JC virus in the urine, and fi nally, when performed on the biopsy sample it detected more than 106 copies of JC virus DNA, which allowed us to establish JC virus-associated nephropathy as a defi nitive diagnosis. The patient was treated with intravenous immunoglobulins and reduction of immunosuppression. Serum creatinine returned to initial levels with decrease of proteinuria. This case documents that JC virus may cause signifi cant changes in renal allograft and should be included in the differential diagnosis of allograft dysfunction.

Ključne riječi

immunosuppression; kidney transplantation; JC virus; JC virus nephropathy

Hrčak ID:

245739

URI

https://hrcak.srce.hr/245739

Datum izdavanja:

6.11.2020.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.463 *