Croatica Chemica Acta, Vol. 29 No. 3-4, 1957.
Izvorni znanstveni članak
The Synthesis of 14C Labelled Serotonin/2-(5' -Hydroxyindolyl-3')-ethylamine-[l-14C]/
D. Keglević-Brovet
; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia
S. Kveder
; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia
S. Iskrić
; Tracer Laboratory, Institute »Ruder Bošković « Zagreb, Croatia, Yugoslavia
Sažetak
By modification of published procedure s on the 2-(indolyl)-3') ethylamines syntheses it' was possible to obtain 2-(5'-benzylox yindolyl-3')-acetonitrile-[1-14C) (III) in a 820/o yield, from equimolar amounts of 5-benzyloxygramine methosulphate (II) (1.1 mM) and sodium cyanide-UC (1.0 mM, 1 mC). III was reduced with lithium aluminium hydride to the corresponding amine IV, catalitically debenzylated to serotonin V and isolated as crea tinine sulphate complex VI in a 640/o yield (calc'd on Nat4CN), having a specific activity of 1.71 μC/mg. (0.69 mC/ mM).
Ključne riječi
Hrčak ID:
246316
URI
Datum izdavanja:
30.12.1957.
Posjeta: 537 *