Stručni rad
https://doi.org/10.20471/LO.2020.48.02-03.11
Overall survival and disease control rates for operable invasive breast cancer in the era of conservative surgery; retrospective, institutional, and five-year follow-up data
Ana Car-Peterko
orcid.org/0000-0003-3148-0126
; Department of General Surgery and Surgical Oncology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Manuela Avirović
orcid.org/0000-0002-6601-7521
; University of Rijeka, Faculty of Medicine, Department of General Pathology and Pathologic Anatomy, Rijeka, Croatia
Iva Skočilić
; Department of Radiotherapy and Oncology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Petra Valković-Zujić
; Department of Radiology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Ingrid Belac-Lovasić
; Department of Radiotherapy and Oncology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Franjo Lovasić
; Department of General Surgery and Surgical Oncology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Sažetak
Background: Following breast cancer treatment recommendations, the conservative approach is accepted and highly respected in the Clinical Hospital Center (CHC) Rijeka. However, we have found that institutional follow-up data are lacking. This retrospective analysis aims to update institutional data on survival and disease control rates.
Methods: From 2011 till 2014, 915 breast cancer patients underwent surgery at CHC Rijeka, and 615 were included in this analysis. The Institutional Ethics Committee approved the analysis.
Results: All patients were female, and the average age was 59 years. In the 5-year postoperative period, local, regional, and distant recurrence-free survival rates and overall survival and disease-free survival were calculated. All rates negatively correlate with a higher T and N status and a higher stage of the disease. The analysis has also demonstrated that in the pT1-3 pN0-1 subgroup, sentinel lymph node biopsy (SLNB) was not inferior to axillary lymph node dissection (ALND) in terms of locoregional control of disease and overall survival.
Conclusion: Besides updating institutional data, the analysis confirmed that overall survival and locoregional control of the disease in the upfront-surgery patients are similar between pN0 and pN1 subpopulations and between pN2 and pN3, but statistically significantly different between pN0-1 and pN2-3. Currently ongoing, prospective observational multicenter clinical trial aims to translate the significance of these results into the neoadjuvant era.
Ključne riječi
breast cancer; survival; recurrence
Hrčak ID:
250271
URI
Datum izdavanja:
21.12.2020.
Posjeta: 2.148 *