Veterinarski arhiv, Vol. 91 No. 2, 2021.
Izvorni znanstveni članak
https://doi.org/10.24099/vet.arhiv.1245
Pathomorphological features and mast cell count in canine visceral hemangiosarcomas
Andrea Gudan Kurilj
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Krešimir Severin
; Department of Forensic and Juridical Veterinary Medicine, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marko Hohšteter
orcid.org/0000-0001-8844-2660
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Branka Artuković
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Željko Grabarević
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Doroteja Huber
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Lidija Medven Zagradišnik
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivana Mihoković Buhin
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivan-Conrado Šoštarić-Zuckermann
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Visceral hemangiosarcoma were analyzed at the Department of Veterinary Pathology of the Faculty of Veterinary Medicine, University of Zagreb, over a 5-year period. From a total of 52 tumor masses in a total of 31 dogs, histological growth patterns (cavernous, capillary or solid) and the amount of tumor supporting stroma were evaluated. Additionally, sections were stained with toluidine blue for the purpose of mast cell detection and their number was determined in the tumor parenchyma, tumor stroma and edges. The average age of the affected animals was 10 years, males predominated, and the tumors occurred most frequently in cross breeds, German Shepherd dogs and Labrador Retrievers. The highest number of visceral hemangiosarcoma was found in the spleen (27/52). The most common growth pattern of visceral hemangiosarcoma was solely cavernous with a mixture of cavernous and solid patterns in different proportions. Mast cells were found in 44/52 (84.6%) of the visceral hemangiosarcomas. A smaller number of mast cells were found in the tumor parenchyma, and higher number were found in the stroma and tumor edges. The number of mast cells in tumors was not significantly associated with the tumor growth pattern, but there was a positive correlation between MCC - tumor parenchyma and stroma (rs = 0.28, P<0.05), MCC - tumor stroma + edges (rs = 0.74, P<0.05) and MCC - tumor parenchyma and MCC- tumor stroma+edges (rs = 0.30, P<0.05) in all the examined tumors. In splenic tumors, there was only a significant positive correlation between MCC - stroma+edges (rs P = 0.68 P<0.05). These results suggest a higher mast cell count in tumors with more developed stromal components in canine visceral hemangiosarcomas, and certainly indicate the need for further research on their role and the factors they release in the development and progression of hemangiosarcomas.
Ključne riječi
dog; visceral hemangisarcoma; mast cell; stroma
Hrčak ID:
258463
URI
Datum izdavanja:
8.6.2021.
Posjeta: 1.184 *