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THE CONTROLLING NUTRITIONAL STATUS (CONUT) SCORE MIGHT PREDICT SURVIVAL IN MAINTENANCE HEMODIALYSIS PATIENTS
GORDAN BABIĆ
; Opća bolnica Šibensko-kninske županije, Odjel interne medicine, Šibenik, Hrvatska
IVAN KREČAK
; Opća bolnica Šibensko-kninske županije, Odjel interne medicine, Šibenik, Hrvatska
VESNA ROŽANKOVIĆ ČOBANOV
; Opća bolnica Šibensko-kninske županije, Odjel interne medicine, Šibenik, Hrvatska
SANDRA PETKOVIĆ
; Opća bolnica Šibensko-kninske županije, Odjel interne medicine, Šibenik, Hrvatska
MARIJANA GULIN
; Opća bolnica Šibensko-kninske županije, Odjel interne medicine, Šibenik, Hrvatska
Sažetak
Malnutrition causes substantial morbidity in maintenance hemodialysis (HD) patients. The Controlling Nutritional Status (CONUT) has emerged as a simple and an easily obtainable tool to comprehensively assess nutrition as it consists of serum albumin levels, absolute lymphocyte counts, and total cholesterol levels. The CONUT has been shown to predict overall survival (OS) in peritoneal dialysis patients. This study investigated whether CONUT might also predict OS in maintenance HD patients. Clinical and laboratory data were retrospectively collected. Survival time was calculated from the fi rst HD until death or last follow-up; survival analyses were performed using the methods of Kaplan-Meier and Cox regression analysis. Eighty-nine patients were included; mean age was 65.76 years (±14), 35 (39.3%) were female, and the mean CONUT was 3. Higher CONUT score correlated with lower low-density liproprotein, higher serum creatinine, higher serum C-reactive protein and higher neutrophil-to-lymphocyte ratio, as well as with a higher incidence of nephrotic proteinuria (p<0.050 for all analyses). Univariately, patients with higher CONUT (≥5) had an inferior OS (median 54 vs. 112 months, HR 2.27; p=0.013). In the Cox regression analysis, higher CONUT remained independently associated with inferior OS (HR 9.50; p=0.002) when adjusted to age, sex, diabetes mellitus and nephrotic proteinuria. Therefore, the CONUT score might identify HD patients at an increased risk of death; however, future studies are needed to elucidate whether CONUT score might be able to guide nutritional support in HD patients.
Ključne riječi
malnutrition; inflammation; survival; CONUT; hemodialysis
Hrčak ID:
261246
URI
Datum izdavanja:
10.8.2021.
Posjeta: 1.141 *