Izlaganje sa skupa
FROM FAMILY SURROUNDINGS TO INTESTINAL FLORA, A LITERATURE REVIEW CONCERNING EPIGENETIC PROCESSES IN PSYCHIATRIC DISORDERS
Thomas Dubois
; Université Catholique de Louvain, Psychosomatic Department, Mont-Godinne University Hospital, Yvoir, Belgium
Christine Reynaert
; Université Catholique de Louvain, Psychosomatic Department, Mont-Godinne University Hospital, Yvoir, Belgium
Denis Jacques
; Université Catholique de Louvain, Psychosomatic Department, Mont-Godinne University Hospital, Yvoir, Belgium
Brice Lepiece
; Université Catholique de Louvain, Psychosomatic Department, Mont-Godinne University Hospital, Yvoir, Belgium
Nicolas Zdanowicz
; Université Catholique de Louvain, Psychosomatic Department, Mont-Godinne University Hospital, Yvoir, Belgium
Sažetak
Background: Some behaviors or psychiatric conditions seem to be inherited from parents or explain by family environment. We
hypothesized interactions between epigenetic processes, inflammatory response and gut microbiota with family surroundings or
environmental characteristics.
Subjects and methods: We searched in literature interactions between epigenetic processes and psychiatric disorders with a
special interest for environmental factors such as traumatic or stress events, family relationships and also gut microbiota. We
searched on Pubmed, PsycINFO, PsycARTICLES and Sciencedirect articles with the keywords psychiatric disorders, epigenome,
microbiome and family relationships.
Results: Some gene polymorphisms interact with negative environment and lead to psychiatric disorders. Negative environment
is correlated with different epigenetic modifications in genes implicated in mental health. Gut microbiota diversity affect host
epigenetic. Animal studies showed evidences for a transgenerational transmission of epigenetic characteristics.
Conclusions: Our findings support the hypothesis that epigenetic mediate gene-environment interactions and psychiatric
disorders. Several environmental characteristics such as traumatic life events, family adversity, psychological stress or internal
environment such as gut microbiota diversity and diet showed an impact on epigenetic. These epigenetic modifications are also
correlated with neurophysiological, inflammatory or hypothalamic-pituitary-adrenal axis dysregulations.
Ključne riječi
disorders; epigenome; microbiome; family
Hrčak ID:
262509
URI
Datum izdavanja:
24.3.2020.
Posjeta: 283 *