Pregledni rad
COMPLICATION AND PROGNOSIS OF JUVENILE IDIOPATHIC ARTHRITIS ASSOCIATED UVEITIS IN THE ERA OF MODERN IMMUNOMODULATORY TREATMENT
Marija Barišić Kutija
; 1Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Sanja Perić
; Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Josip Knežević
; Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Zlatko Juratovac
; Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Nenad Vukojević
; Zagreb University Hospital Centre, Department of Ophthalmology, Zagreb, Croatia
Sažetak
JIA is the most common rheumatic disease of childhood and JIA-U is its most frequent and most devastating extraarticular manifestation. This form of uveitis is usually asymptomatic, chronic anterior uveitis, often accompained with complications. JIA-U is the main cause of vision loss and even blidness in childhood. Thus, screening for JIA-U in all JIA patients and early treatment is of prime importance. Over the last 15-20 years, ever since IMT has been used, studies generally show trends toward decrease of JIA-U onset, complications frequency, improvement of prognosis and remission achievement. Despite evident improvements, over 20% JIA-U patients still develop complications in long-term follow-up. Moreover, about 50% JIA-U patients continue to have active uveitis in adulthood. Therefore, JIA-U is still associated with high risk of late sequelae and visual acuity loss, functionally and structurally eye damage and quality of life impairment.
Ključne riječi
juvenile idiopathic arthritis (JIA); juvenile idiopathic arthritis-associated uveitis (JIA-U); complication; prognosis; visual acuity; remission
Hrčak ID:
262698
URI
Datum izdavanja:
4.4.2019.
Posjeta: 387 *