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Psychiatria Danubina, Vol. 27 No. suppl 1, 2015.

Conference paper

MODERN INDICATIONS FOR THE USE OF OPIPRAMOL

Krzysztof Krysta ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland
Sławomir Murawiec ; “Dialogue” Therapy Centre, Warsaw, Poland
Anna Warchala ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland
Karolina Zawada ; Department of Pneumonology, Medical University of Silesia, Katowice, Poland
Wiesław J. Cubała ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Mariusz S. Wiglusz ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Katarzyna Jakuszkowiak-Wojten ; Department of Psychiatry, Medical University of Gdańsk, Gdańsk, Poland
Marek Krzystanek ; Department of Rehabilitation Psychiatry, Medical University of Silesia, Katowice, Poland
Irena Krupka-Matuszczyk ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland

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Abstract

Opipramol is considered as a pharmacological agent that does not fit the classification taking into account the division of
antidepressants, antipsychotics and anxiolytics. It has a structure related to tricyclic antidepressants but it has a different mechanism
of action, i.e. binding to sigma1 and to sigma2 sites. It has been regarded as an effective drug in general anxiety disorders together
with other agents like SSRI`s, SNRI`s, buspirone and pregabalin for many years. It can however also be indicated in other
conditions, e.g. it may be used as a premedication in the evening prior to surgery, positive results are also observed in
psychopharmacological treatment with opipramol in somatoform disorders, symptoms of depression can be significantly reduced in
the climacteric syndrome. The latest data from literature present also certain dangers and side effects, which may result due to
opipramol administration. Mania may be induced not only in bipolar patients treated with opipramol, but it can be an adverse drug
reaction in generalized anxiety disorder. This analysis shows however that opipramol is an important drug still very useful in
different clinical conditions.

Keywords

opipramol; depression; anxiety disorders; somatoform disorders

Hrčak ID:

264585

URI

https://hrcak.srce.hr/264585

Publication date:

8.9.2015.

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