Izlaganje sa skupa

EVALUATION OF THE CORTISOL CONCENTRATIONS IN PATIENTS WITH SCHIZOPHRENIA

Dominika Tobolska ; Students’ Scientific Association in Department of Pediatrics, Medical University of Silesia, Katowice, Poland
Krzysztof Maria Wilczyński ; Students' Scientific Association in Department of Psychiatric Rehabilitation, Medical University of Silesia, Katowice, Poland
Miłosz Lorek ; Students’ Scientific Association in Department of Pediatrics, Medical University of Silesia, Katowice, Poland
Elżbieta Mazgaj ; Students' Scientific Association in Department of Psychiatric Rehabilitation, Medical University of Silesia, Katowice, Poland
Krzysztof Krysta ; Department of Psychiatric Rehabilitation, Medical University of Silesia, Katowice, Poland
Aneta Gawlik ; Department of Pediatrics, Medical University of Silesia, Katowice, Poland
Marek Krzystanek ; Department of Psychiatric Rehabilitation, Medical University of Silesia, Katowice, Poland

Sažetak

Introduction: The hypothalamus-pituitary-adrenal axis (HPAA) plays a pivotal role in response to a range of external and
internal factors often described as a “stress”. Growing evidence in a literature, suggest various dysregulations of HPAA, in course
of numerous mental disorders. Patients with schizophrenia and bipolar disorder seem to have elevated basal cortisol secretion, what
might be caused by the diminution of glucocorticoid receptors’ amount. It was of the interest if the cortisol concentrations in patients
with diagnosed schizophrenia who underwent treatment, differs from healthy individuals.
Materials and methods: Two groups of participants were included into the study. First group (study) consisted of 10 patients
with diagnosed schizophrenia and control group which included 38 healthy individuals. Study was divided into two stages, first one
(pilot) included only control group, and utilized cortisol concentrations measurement from saliva, blood and 24h urine sample.
Second part (main study) involved both groups although focused on a salivary cortisol concentrations.
Results: A mean salivary cortisol concentration in patients with schizophrenia who underwent treatment was significantly lower
in comparison with healthy individuals.
Conclusions: Obtained results indicate that patients who underwent a treatment, and does not present notable clinical signs of
schizophrenia may have moderately lowered levels of salivary cortisol. This may be a reflection of relenting psychotic symptoms as
well as a direct effect of atypical antipsychotic drugs on a HPA axis activity.

Ključne riječi

cortisol; schizophrenia; treatment

Hrčak ID:

264923

URI

https://hrcak.srce.hr/264923

Datum izdavanja:

30.8.2016.

Posjeta: 324 *