Stručni rad
https://doi.org/10.33128/s.75.1-2.7
LEUKOCYTE ADHESION DEFICIENCY – AN INHERITED DISORDER IN CATTLE
Aneta Piplica
orcid.org/0000-0003-2778-7889
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ivan Conrado Šoštarić–Zuckermann
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Anamaria Ekert Kabalin
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Velimir Sušić
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ivan Vlahek
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Ivana Sabolek
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Mario Ostović
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Sven Menčik
; Veterinarski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Sažetak
In domestic animals, inherited disorders may be species-specific or breed-specific. Leukocyte adhesion deficiency in cattle is an inherited disease that occurs in Holstein breed and its crossbreeds, and affects health, causes the death of calves, results in reduced productivity of breeding animals, and significant economic losses in production. The disease occurs as a result of a mutation in the gene responsible for the expression of receptors on the surface of white blood cells resulting in reduced activity or a complete lack of proteins involved in the inflammatory response. The incidence of the disease in the population ranged to 21.5%. The application of modern molecular genetic methods is extremely important in the identification of carriers and has contributed to the reduction of the number of animals carrying the recessive allele. Strategies for maintaining a low number of diseased animals as well as carriers of the recessive allele include regular genotyping of breeding bulls and cows before introduction into breeding as part of breeding programs and genomic evaluation of animals.
Ključne riječi
inherited disorders; cattle; Holstein breed; ITGB2 gene; β2 integrins
Hrčak ID:
265866
URI
Datum izdavanja:
9.7.2021.
Posjeta: 1.341 *