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SIBUTRAMINE-ASSOCIATED PSYCHOTIC SYMPTOMS AND ZOLPIDEM-INDUCED COMPLEX BEHAVIOURS: IMPLICATIONS FOR PATIENT SAFETY

Mariusz S. Wiglusz ; Department of Psychiatry, Medical University of Gdańsk, Poland
Wiesław Jerzy Cubała ; Department of Psychiatry, Medical University of Gdańsk, Poland
Paweł Nowak ; Department of Psychiatry, Medical University of Gdańsk, Poland
Katarzyna Jakuszkowiak-Wojten ; Department of Psychiatry, Medical University of Gdańsk, Poland
Jerzy Landowski ; Department of Psychiatry, Medical University of Gdańsk, Poland
Krzysztof Krysta ; Department of Psychiatry and Psychotherapy, Medical University of Silesia, Katowice, Poland

Sažetak

Background: Sibutramine is a weight loss agent recently withdrawn from the European market due to cardiovascular risk
concerns. It was used for long–term obesity treatment. Zolpidem is a short acting hypnotic agent commonly used in the treatment of
insomnia. A number of case reports describing psychotic reaction to sibutramine were reported in the literature.
Case report: We present a case of a 61–year–old Caucasian woman who developed two psychotic episodes related to
sibutramine treatment. The second psychotic episode was complicated with complex behaviours after zolpidem use due to insomnia.
Sibutramine and zolpidem discontinuation resulted in rapid resolution of psychotic symptoms.
Conclusions: This case suggests a possibility of incidence of psychotic symptoms and complex behaviour disturbances in
patients prescribed sibutramine or other monoaminergic reuptake inhibitors.

Ključne riječi

sibutramine; zolpidem; adverse drug reaction

Hrčak ID:

266478

URI

https://hrcak.srce.hr/266478

Datum izdavanja:

26.8.2013.

Posjeta: 813 *