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Acta clinica Croatica, Vol. 60. No. 3., 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.03.03

ABO Blood Group Genotypes in Women with Breast Cancer

Tamara Bezek ; Molecular Diagnostics Department, Croatian Institute of Transfusion Medicine, Zagreb, Croatia
Jasna Bingulac-Popović orcid id orcid.org/0000-0002-9449-3154 ; Molecular Diagnostics Department, Croatian Institute of Transfusion Medicine, Zagreb, Croatia
Dinko Bagatin ; Bagatin Clinic, Zagreb, Croatia; Faculty of Dental Medicine and Health in Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia
Roberta Petlevski ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Irena Jukić orcid id orcid.org/0000-0003-2778-8400 ; Medical Department, Croatian Institute of Transfusion Medicine, Zagreb, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

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Abstract

ABO blood group is a risk factor for several cancers, but it is not clear yet whether
the risk of breast cancer is greater in particular ABO blood type carriers. The aim of this casecontrol
study was to examine the correlation between ABO blood group genotypes, estrogen receptor
(ER), progesterone receptor (PR) and HER2 status as tumor grade markers (I-III), and the occurrence
of breast cancer. The research included 59 patients with invasive breast cancer and 80 asymptomatic,
healthy women, blood donors. Genomic DNA was isolated using QIAampDNA Blood Mini Kit
(QIAGEN, Germany). Genotyping was performed using in-house polymerase chain reaction with
sequence-specific primers (PCR-SSP) method. Comparison of genotypes and phenotypes of ABO
blood groups between patients and control group yielded p>0.05. There was no statistical significance
of correlation between ABO genotypes/phenotypes in either patient group or control group. Testing
the significance of different tumor grade occurrence, and ER, PR and HER2/neu status showed no
statistical significance in the occurrence of a particular tumor grade, or in ER, PR and HER2/neu
status as tumor markers in O1A1 genotype compared to non-O1A1 genotypes. Our study results
confirmed that there was no correlation between ABO blood type genotypes/phenotypes and breast
cancer in study groups.

Keywords

ABO blood groups; Breast cancer; ABO genotypes; ABO phenotypes

Hrčak ID:

271322

URI

https://hrcak.srce.hr/271322

Publication date:

1.9.2021.

Article data in other languages: croatian

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