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Acta clinica Croatica, Vol. 60. No. 3., 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.03.20

Subclinical Hypothyroidism as a Contributor to Macrovascular Complications in Patients with Type 2 Diabetes Mellitus

Mariya Marushchak ; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Iryna Vivsiana ; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Volodymyr Musiienko ; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Inna Krynytska ; Department of Functional and Laboratory Diagnostics, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Kateryna Kozak ; Department of Pediatrics N2, I Horbachevsky Ternopil National Medical University, Ternopil, Ukraine

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Abstract

This study aimed to evaluate changes of the lipid panel data in patients with comorbid
type 2 diabetes mellitus (T2DM) and subclinical hypothyroidism (SCH) and to identify the
probable prognostic values of the lipid profile for macrovascular complication (MVC) development.
The study included 370 patients presented with only T2DM and 30 patients suffering from both
T2DM and SCH. Receiver operating characteristic (ROC) analysis was used to identify prognostically
significant values of the lipid profile with the optimal ratio of sensitivity and specificity for MVC
development. All lipid profile values in the patients with T2DM combined with SCH were significantly
higher compared to those with only T2DM. At the same time, SCH + T2DM increased the
risk of exceeding target levels of triglycerides by 2.9 times and HDL-C by 4.1 times. Analysis of lipid
profile values according to macrovascular involvement showed that total cholesterol, LDL-C and
non-HDL-C in patients with T2DM and SCH were significantly higher compared to those with
only T2DM. The levels of triglycerides >1.65 mmol/L, non-HDL-C >3.74 mmol/L and remnant
cholesterol >0.74 mmol/L determined by the ROC analysis can be used for stratification of patients
with T2DM combined with SCH into the category of increased risk of MVC development.

Keywords

Diabetes mellitus type 2; Subclinical hypothyroidism; Risk; Dyslipidemia; Macrovascular complications; ROC analysis

Hrčak ID:

271671

URI

https://hrcak.srce.hr/271671

Publication date:

1.9.2021.

Article data in other languages: croatian

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