Izvorni znanstveni članak
https://doi.org/10.20471/may.2022.58.01.10
Could the Type of Delivery Contribute to Clinical Features of Schizophrenia and Nicotine Dependence among Patients Who are not Under Antipsychotic Treatment?
Sergej Nadalin
orcid.org/0000-0002-1601-9094
; Department of Psychiatry, General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia,
Vjekoslav Peitl
orcid.org/0000-0003-4163-6411
; Department of Psychiatry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia, School of Medicine, Catholic University of Croatia, Zagreb, Croatia
Dalibor Karlović
; Department of Psychiatry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia, 3School of Medicine, Catholic University of Croatia, Zagreb, Croatia
Sanja Dević Pavlić
orcid.org/0000-0001-8440-1722
; Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia,
Mislav Škrobo
orcid.org/0000-0002-8174-505X
; Department of Psychiatry, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia
Melita Uremović
; School of Medicine, Catholic University of Croatia, Zagreb, Croatia
Lena Zatković
; Hospital Pharmacy, Clinical Hospital Center Rijeka, Rijeka, Croatia
Alena Buretić-Tomljanović
; Department of Medical Biology and Genetics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Sažetak
The type of delivery and antipsychotic medications could modulate clinical features of schizophrenia and nicotine dependence by affecting gut microbiota composition. In this study, we aimed to investigate whether the age of disease onset, severity of PANSS (Positive and Negative Syndrome Scale) psychopathology and nicotine dependence might be associated with the type of delivery among two groups of patients with schizophrenia without antipsychotic therapy: first-episode patients, and chronic patients, non-adherent to antipsychotic medications. Information regarding antipsychotic non-adherence, smoking status, and the type of delivery (vaginal delivery or caesarean delivery) was obtained from autoanamnestic and heteroanamnestic data. Age of disease onset was defined as age at the patient’s first hospital admission due to a psychotic episode at which the diagnosis of schizophrenia was used. PANSS evaluation data was taken during the acute state of the illness at the most recent hospitalization. Values of the age of disease onset, PANSS score and PANSS factor and prevalence of early (≤ 26 years) and late (> 26 years) disease onset did not differ significantly between patients born by caesarean delivery and vaginal delivery (p > 0.05). The prevalence of smokers was significantly higher among patients born by caesarean delivery (p = 0.012). The caesarean delivery is associated with ~9%-fold greater risk of nicotine dependence. We did not find any associations of the age of disease onset and PANSS psychopathology with the type of delivery among patients without therapy, but our results implicate that caesarean delivery might be a risk factor for nicotine dependence in that patient group.
Ključne riječi
age of onset; caesarean delivery; schizophrenia; smoking
Hrčak ID:
274188
URI
Datum izdavanja:
20.3.2022.
Posjeta: 866 *