Recenzija, Prikaz slučaja
The Pancreatitis, Panniculitis, and Polyarthritis (PPP) Syndrome: Subcutaneous Nodular Fat Necrosis, a Cutaneous Marker of Pancreatic Neoplasia
Małgorzata Bernacka
; Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
Konrad Kosztowny
; Department of Transplant and General Surgery, Medical University of Lodz, Lodz, Poland
Robert A. Schwartz
; Dermatology and Pathology, Rutgers New Jersey Medical School, Newark, New Jersey
Piotr Hogendorf
; Department of Transplant and General Surgery, Medical University of Lodz, Lodz, Poland
Jarosław Bogaczewicz
; Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
Anna Woźniacka
; Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland
Sažetak
The pancreatitis, panniculitis, polyarthritis (PPP) syndrome
is a rare skin, joint, and pancreatic disorder, also known as subcutaneous
nodular fat necrosis. It results from obstruction of pancreatic ducts
with direct secretion of pancreatic enzymes into the bloodstream,
causing extra pancreatic fat necrosis with subcutaneous tissue and
joint inflammation. It is usually a cutaneous sign of pancreatic cancer
or pancreatitis. To our knowledge, this is the first case associated with
a pancreatic pseudotumor. We describe a 59-year-old man initially presenting
with numerous painful erythematous subcutaneous nodules
due to a fibrous pancreatic pseudotumor and its extreme dermatologic
disease, resulting in necrosis of the shin and foot so severe that an amputation
of the lower leg above the knee was required, a complication
not previously described, to our knowledge. We emphasize that PPP
syndrome is a cutaneous marker of internal malignancy, most often of
pancreatic cancer or pancreatitis, but in this case of a rare pancreatic
pseudotumor.
Ključne riječi
Pancreatitis, Panniculitis, Polyarthritis
Hrčak ID:
274444
URI
Datum izdavanja:
17.3.2021.
Posjeta: 1.142 *