Case report
Symmetrical Skin Lesions on the Gluteal Region in a Patient with Anti-Laminin-332 Mucous Membrane Pemphigoid
Nobuki Maki
; Department of Dermatology, Akita National Hospital, Akita, Japan
Toshio Demitsu
; Department of Dermatology, Jichi Medical University Saitama Medical Center, Saitama, Japan
Hajime Nagato
; Nagato Dermatology Clinic, Chiba, Japan
Osamu Okada
; Okada Dermatological Clinic, Akita, Japan
Kozo Yoneda
; Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Osaka Ohtani University, Osaka, Japan
Takashi Hashimoto
; Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan
Naoko Hasunuma
; Department of Medical Education, Graduate School of Biochemical and Health Sciences, Hiroshima University, Hiroshima, Japan
Shin-Ichi Osada
; Department of Dermatology, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
Motomu Manabe
; Department of Dermatology, Akita National Hospital, Akita, Japan
Abstract
Mucous membrane pemphigoid (MMP), previously
called cicatricial pemphigoid, is a rare subepidermal
immunobullous disorder that primarily affects
the mucous membranes (1,2). MMP is divided
into two major subtypes, anti-BP180-type MMP and
anti-laminin-332 (previously called laminin 5 or epiligrin)
MMP. Anti-laminin-332 MMP is known to be
associated with malignant tumors (3), which may
cause overexpression of autoantibodies and induce
autoimmunity to laminin-332 (4). MMP primarily affects
the mucous membranes, and widespread skin
lesions are rare. In MMP, circumscribed skin lesions
have been previously reported as occurring on the
head, neck, and upper trunk (5). We report a case of
anti-laminin-332 MMP presenting with symmetrical
skin lesions characteristic of MMP on the weightbearing
areas of the gluteal region
Keywords
Hrčak ID:
274477
URI
Publication date:
11.5.2021.
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