Izvorni znanstveni članak
Psoriasis and 5HT-R2C Gene Polymorphism: Association between Clinical, Demographic and Therapeutic Parameters in the Turkish Population
Sehime G. Temel
; Department of Medical Genetic, Bursa Uludag University Faculty of Medicine, Turkey
Serkan Yazici
; Department of Dermatology and Venereology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey
İzel Yilmaz
; Department of Medical Immunology, Bursa Uludag University, Institute of Health Science, Bursa, Turkey
Özgür Tosun
; Department of Biostatistics, Near East University, Faculty of Medicine, Nicosia, Cyprus
Mahmut Cerkez Ergoren
; Department of Medical Genetics, Near East University Faculty of Medicine, Nicosia, Cyprus
Emel Bulbul Baskan
; Department of Dermatology and Venereology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey
Barbaros Oral
; Department of Immunology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey
Kenan Aydogan
; Bursa Uludag University School of Medicine, Department of Dermatology and Venereology, Bursa, Turkey
Sažetak
We aimed to investigate the relationship between single
nucleotide polymorphism (SNP) in the promoter region of the 5-HT-R2C
gene and stress-related disease psoriasis in the Turkish population. The
putative association between the 5-HTR2C variant (rs6318 Cys23Ser allele)
and patients with psoriasis was investigated. 100 patients with psoriasis
and 100 age-sex matched, unrelated healthy subjects representing
the control group were included in the study. The PCR-RFLP method
was used for genotyping the 5-HTR2C variation. There was no statistically
difference in terms of genotype distributions and allele frequencies
between the control subjects and patients with psoriasis (P=0.360
and P=0.439, respectively). The comparison between the presence and
absence of the 5-HTR2C gene rs6318 G allele within the determined
clinical subsets resulted in a significant difference with regard to treatment
methodology only when conventional therapy and one or more
medical therapy was compared (P=0.021). This study is the first clinical
study to investigate the association between 5-HTR2C polymorphism
and psoriasis. The role of the 5-HTR2C gene should be examined with
more parameters in a larger case series.
Ključne riječi
psoriasis, serotonin, stress, 5-HT-R2C, rs6318 Cys23Ser
Hrčak ID:
274485
URI
Datum izdavanja:
15.9.2021.
Posjeta: 429 *