Izlaganje sa skupa
KETAMINE - UNDRAWN LINES BETWEEN MEDICAL AND RECREATIONAL USE - IMPLICATIONS FOR CLINICAL PRACTICE
Suzana Jonovska
; Department of Addictions and Psychotrauma, Psychiatric Hospital Rab, Rab, Croatia ; Faculty of Health Studies, Rijeka, Croatia
Tom Sugnet
; Department of Addictions and Psychotrauma, Psychiatric Hospital Rab, Rab, Croatia
Vesna Šendula- Jengić
; Faculty of Health Studies, Rijeka, Croatia ; Research Department, Psychiatric Hospital Rab, Rab, Croatia
Sažetak
Ketamine, synthesized in 1962, approved in 1970, is considered safe for use in controlled conditions, mainly as an anesthetic,
especially in pediatric populations and in people suffering from pulmonary diseases, as well as in emergency departments and in war
situations. Dissociative states (derealization and depersonalization) produced by ketamine made it a popular recreational drug,
which led to increased regulation in most countries. Intravenous application of ketamine has shown rapid, although transitory
antidepressant and antisuicidal effects in patients with unipolar and bipolar depression. Esketamine, the S(+) enantiomer of
ketamine, with better pharmacodynamic selectivity, has just been approved for treatment-resistant major depressive disorder, in the
form of a nasal spray. Presently, the high cost of the spray not only limits its widespread use, but also makes it less prone to abuse
and diversion. Additional measures are needed to hinder it from becoming a new "street drug".
Ključne riječi
ketamine; esketamine; antidepressant; ketamine abuse
Hrčak ID:
275068
URI
Datum izdavanja:
19.10.2021.
Posjeta: 531 *