Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2022.51

SERUM TUMOR NECROSIS FACTOR-LIKE WEAK INDUCER OF APOPTOSIS (TWEAK) LEVELS ARE DECREASED IN CHILDREN WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER

Ümit Işık ; Department of Child and Adolescent Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
Faruk Kılıç ; Department of Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
Arif Demirdaş ; Department of Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
Evrim Aktepe ; Department of Child and Adolescent Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey
Pınar Aydoğan Avşar ; Department of Child and Adolescent Psychiatry, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey

Sažetak

Introduction: There has been no study in the literature evaluating serum tumor necrosis factor-like weak inducer of apoptosis
(TWEAK) levels in attention-deficit/hyperactivity disorder (ADHD). Therefore, we performed the present study to specifically measure
serum TWEAK levels to see whether or not its eventual alterations might have an etiopathogenetic significance in children with ADHD.
Subjects and methods: A total of 49 treatment-naive children with ADHD and 39 healthy controls were included in the present
study. The severities of ADHD and conduct disorder symptoms were assessed via parent- and teacher-rated questionnaires. Venous
blood samples were collected, and serum TWEAK levels were measured.
Results: Serum TWEAK levels of the ADHD group were significantly lower than the control group.
Conclusions: This study shows that ADHD patients have decreased serum TWEAK levels, suggesting a possible involvement of
TWEAK in the etiopathogenesis of ADHD.

Ključne riječi

attention; deficit/hyperactivity disorder; ADHD; cytokine; TWEAK

Hrčak ID:

275939

URI

https://hrcak.srce.hr/275939

Datum izdavanja:

3.5.2022.

Posjeta: 706 *