Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.52
Fecal microbiota transplantation – where are we?
Ivana Mikolašević
; Department of Gastroenterology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Goran Hauser
; Department of Gastroenterology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Maja Abram
; Faculty of Medicine, University of Rijeka, Rijeka, Croatia
Tajana Filipec Kanižaj
; Department of Gastroenterology, Merkur University Hospital, Zagreb, Croatia
Marija Radić
; Zagreb University School of Medicine, Zagreb, Croatia
Irena Krznarić Zrnić
; Department of Gastroenterology, Clinical Hospital Center Rijeka, Rijeka, Croatia
Sažetak
In addition to its antimicrobial protective role, the gut microbiota affects human metabolism and immunity as well
as inflammatory and neuro-hormonal responses. Due to its
beneficial effects on health even up to the genetic level, it
is referred to as a “forgotten organ,” “virtual organ,” or “other
brain” (1). The human gut microbiome differs among individuals and usually does not change over time. Its composition is affected by several environmental factors (1-3).
Fecal microbiota transplantation (FMT) or bacteriotherapy
(health donor stool transplantation) is the instillation of a
fecal suspension taken from a healthy donor into the upper or lower gastrointestinal (GI) tract of a patient, with an
aim to enrich and normalize his or her gut microbiota. Although the method has been known for centuries, interest
in it has significantly grown over the last few decades. The
two main reasons are the global epidemic of Clostridioides
difficile (CDI) infection and an improved knowledge of the
GI microbiome and its involvement in various conditions. It
seems that FMT may also transfer host phenotype
Ključne riječi
Hrčak ID:
278030
URI
Datum izdavanja:
25.2.2021.
Posjeta: 370 *