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Libri Oncologici : Croatian Journal of Oncology, Vol. 38 No. 1-3, 2010.

Izvorni znanstveni članak

Mucinous component in colorectal carcinoma – influence on survival

Mario Kopljar ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia
Vladimir Blagaić ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia
Alenka Boban-Blagaić ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia
Leonardo Patrlj ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia
Kristijan Ćupurdija ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia
Bore Bakota ; Department of Surgery, University Hospital Dubrava, Zagreb, Croatia

Puni tekst: engleski pdf 83 Kb

str. 17-22

preuzimanja: 122

citiraj

Sažetak

AIM. Clinical significance of mucin component in colorectal cancer is still unclear. We compared clinical and pathological features of mucinous and non-mucinous colorectal cancers and assessed the impact of mucinous differentiation and other specific features of colorectal cancer on survival. PATIENTS AND METHODS. We analyzed clinical and pathological data of 271 patients who underwent surgical resection of colorectal adenocarcinoma at our Department between 1994 and 2002. RESULTS. Patients with mucinous colorectal cancer had worse overall survival, but not statistically significant (P=0.296). In a multivariate model, only tumor size, the presence of hepatic metastases, and the presence of metastases in lymph nodes, but not mucinous differentiation, were found to be significant and independent predictors of survival. CONCLUSION. The results of this study confirm the frequent observation that mucinous colorectal cancer is associated with worse prognosis compared to non-mucinous type. However, these results do not provide evidence that mucinous differentiation is independently associated with more aggressive tumor behavior. Current findings justify surgical resection of all gross tumor deposits, together with the employment of perioperative intraperitoneal chemotherapy in the treatment of patients with mucinous colorectal cancer.

Ključne riječi

adenocarcinoma, mucinous; colorectal neoplasms; survival analysis; colonic neoplasms -pathology; colonic neoplasms - surgery; rectal neoplasms – pathology; rectal neoplasms - surgery

Hrčak ID:

278527

URI

https://hrcak.srce.hr/278527

Datum izdavanja:

21.10.2010.

Podaci na drugim jezicima: hrvatski

Posjeta: 838 *