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Acta clinica Croatica, Vol. 60. No. Supplement 3, 2021.

Book review

https://doi.org/10.20471/acc.2021.60.s3.06

Delayed effect of VNS on interictal epileptiform discharges and pharmacoresistance in a patient with refractory perinatal postischemic epilepsy

Davor Sporiš ; Department of Neurology, Dubrava University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; University of Applied Health Science in Zagreb, Zagreb, Croatia
Silvio Bašić ; Department of Neurology, Dubrava University Hospital, Zagreb, Croatia
Darko Chudy ; Department of Neurosurgery, Dubrava University Hospital, Zagreb, Croatia
Ivana Šušak Sporiš ; Department of Neurology, Dubrava University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; University of Applied Health Science in Zagreb, Zagreb, Croatia
Ivana Marković ; Department of Neurology, Dubrava University Hospital, Zagreb, Croatia; Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; University of Applied Health Science in Zagreb, Zagreb, Croatia

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Abstract

A 20-year-old female with refractory perinatal postischemic catastrophic epilepsy
and frequent daily generalized atonic, tonic, tonic-clonic and focal seizures was hospitalized in the
progressive phase of illness. The diagnosis was confirmed by semiology, interictal electroencephalogram
(EEG), long-term video EEG monitoring, and brain magnetic resonance imaging. Repeated
interictal EEG findings showed generalized spike and slow wave complexes with a 2-3 Hz frequency.
Interictal EEG showed evidence of electroclinical epileptic status on several occasions. She was treated
with various antiepileptic drugs without improvement. After verification of her incompetence for
normal autonomous living, which resulted in very low quality of life, this patient with refractory epilepsy
underwent implantation of vagus nerve stimulator (VNS). In this case report, we present delayed
effect of VNS on interictal epileptiform discharges and pharmacoresistance.

Keywords

Epilepsy; Pharmacoresistance; Interictal epileptiform discharges; Vagus nerve stimulation

Hrčak ID:

285129

URI

https://hrcak.srce.hr/285129

Publication date:

31.12.2021.

Article data in other languages: croatian

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