Reumatizam, Vol. 68 No. 2, 2021.
Pregledni rad
https://doi.org/10.33004/reumatizam-68-2-5
THERAPEUTIC APPROACH TO A PATIENT WITH ANTISYNTHETASE SYNDROME – A CASE REPORT
Dora Uršić
Ivana Kovačević
Željka Kardum
Kristina Kovačević Stranski
Ana Marija Masle
Ana Kovač
Mirna Lucić
Višnja Prus
Jasminka Milas Ahić
Sažetak
Introduction: Antisynthetase syndrome (ASS) is a rare autoimmune systemic disease characterised by myositis, arthritis, Raynaud’s syndrome, mechanic’s hands, and interstitial lung disease. Materials and methods: We present the case of a 50-year-old patient with predominant signs of polymyositis, pulmonary interstitium involvement and positive anti-Jo1 antibodies with suspected antisynthetase syndrome. Results: He was treated with glucocorticoids and following that the treatment was continued with an additional immunosuppressive therapy drug, azathioprine, which was discontinued due to a liver lesion. The treatment was then continued with cyclophosphamide. In the later course of the disease, radiological regression of pulmonary changes was monitored, and mycophenolate mofetil was introduced as a maintenance therapy. Conclusion: If left unrecognised, ASS can lead to the development of irreversible pulmonary fibrosis. However, timely application of immunosuppressive therapy can improve the quality of life and the prognosis of patients with ASS.
Ključne riječi
antisynthetase syndrome, anti-Jo1 antibody, interstitial lung disease
Hrčak ID:
287145
URI
Datum izdavanja:
4.12.2022.
Posjeta: 476 *