Review article
https://doi.org/10.21857/yvjrdcvx1y
Estimated arterial stiffness and cardiovascular risk in chronic kidney disease – a study protocol
Marija Domislović
Ivan Brzić
Danilo Radunović
Vladimir Prelević
Bojan Jelaković
Abstract
Introduction The prevalence of chronic kidney disease (CKD) in the general population is 9.1%. Cur- rent guidelines recommend a cut-off GFR value of 60 mL/min/1.73 m2 for diagnosis of CKD, without considering the physiological decline of GFR with aging, or the association with cardiovascular (CV), cerebrovascular or renal outcomes. There is also an increase in arterial stiffness with aging, which is es- timated by pulse wave velocity (PWV). Aim The aim of this study is to show how the ePWV predicts CV incidents independently of SCORE chart and traditional risk factors. Materials and Methods This prospective observational study will include 2058 subjects from the Endemic nephropathy in Croatia – epidemiology, diagnosis and etiopathogenesis scientific research project. Conclusion This will be the first study that could show how the estimated arterial stiffness, independently of CKD contributes to overall CV, cerebrovascular and renal risk. We could also, based on the results, propose an age-independent definition of CKD based on the association with CV disease and mortality.
Keywords
chronic kidney disease; ePWV; cardiovascular risk; arterial stiffness
Hrčak ID:
290807
URI
Publication date:
18.12.2022.
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