Review article
https://doi.org/10.21857/ypn4ocd309
State-of-the-art of the Bone Morphogenetic Protein research field: 13th International BMP Conference, Dubrovnik 2022
Nikola Štoković
Natalia Ivanjko
Ivona Matić Jelić
Marina Milešević
Viktorija Rumenović
Valentina Blažević
Lucija Rogina
Ivančica Bastalić
Igor Erjavec
Tatjana Bordukalo Nikšić
Vera Kufner
Dora Adanić
Mihaela Perić
Marko Pećina
T. Kuber Sampath
Slobodan Vukičević
Abstract
The 13th International BMP Conference was held in October 2022 in Dubrovnik. The conference was attended by more than 240 participants from North America, Europe, Asia, and Australia who got an insight into the latest achievements in basic, translational, and clinical research of BMP mol- ecules through 75 lectures categorized into several scientific sections. This review paper provides the most important novel findings on the structure, function, and signaling of BMPs, the role of BMPs in patterning and organoids as well as the role of BMP in metabolism. Moreover, we discussed
the role of BMPs in various diseases including cancer pathogenesis, pulmonary arterial hyperten- sion, and fibrodysplasia ossificans progressiva (FOP). Finally, we provided an overview of the new BMP-based therapies in regenerative medicine that are currently in different stages of preclinical and clinical trials.
Keywords
Bone Morphogenetic Proteins; TGFβ; Regenerative medicine; 13th International BMP Conference;
Hrčak ID:
290813
URI
Publication date:
18.12.2022.
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