Izvorni znanstveni članak
Main Clinical Features of Patients with Irritant and Allergic Contact Dermatitis on the Hands in Correlation with Skin CD44 Expression: A Prospective Study
Gaby Novak-Bilić
; Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia;
Majda Vučić
; Clinical Department of Pathology “Ljudevit Jurak”, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia;
Nives Pondeljak
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 6 Department of Dermatology and Venereology, Sisak General Hospital, Sisak, Croatia
Vedrana Bulat
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia;
Iva Japundžić
; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia;
Liborija Lugović-Mihić
; School of Dental Medicine, University of Zagreb, Zagreb, Croatia; Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia;
Sažetak
Contact dermatitis (CD), including its irritant (ICD) and al-
lergic (ACD) types, is a complex, often chronic and therapy-resistant dis-
ease that significantly affects patient quality of life and healthcare sys-
tems. Objective of this study was to examine the main clinical features
of patients with ICD and ACD on the hands through follow-up in correla-
tion with baseline skin CD44 expression.Our prospective study involved
100 patients with hand CD (50 with ACD; 50 with ICD) who initially un-
derwent biopsies of skin lesions with pathohistology, patch tests to con-
tact allergens, and immunohistochemistry for lesional CD44 expression.
The patients were subsequently followed-up on for a year, after which
they filled out a questionnaire designed by the authors examining dis-
ease severity and disturbances/issues. Patients with ACD had signifi-
cantly higher disease severity than those with ICD (P<0.001), with more
frequent systemic corticosteroid treatments (P=0.026) and greater areas
of affected skin (P=0.006), exposure to allergens (P<0.001), and impair-
ment of everyday activities (P=0.001). No correlation between ICD/ACD
clinical features and initial lesional CD44 expression was observed. Due
to the commonly severe course of CD, especially ACD, more research
and prevention are needed, including the analysis of the role of CD44 in
connection with other cell markers.
Ključne riječi
contact dermatitis, irritant contact dermatitis, allergic con- tact dermatitis, CD44, hand eczema
Hrčak ID:
299623
URI
Datum izdavanja:
14.9.2022.
Posjeta: 267 *