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Acta Dermatovenerologica Croatica, Vol. 30 No. 3, 2022.

Izvorni znanstveni članak

CRP Levels as a Prognostic Factor in Mycosis Fungoides

Evgenya Slutsky Bank ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Mati Rozenblat ; Depart- ment of Dermatology, Ha’emek Medical Center, Afula, Israel
Ori Eytan ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Max Perelman ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Shamir Geller ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Eli Sprecher ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel
Ilan Goldberg ; Division of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Israel

Puni tekst: engleski pdf 186 Kb

str. 140-145

preuzimanja: 114

citiraj

Sažetak

Mycosis Fungoides (MF) and Sézary syndrome (SS) are the most com-
mon forms of cutaneous T-cell lymphomas. Few validated prognostic factors have

been reported in MF/SS, especially when compared with non-cutaneous lympho-
mas. Increased C-reactive protein (CRP) levels have recently been associated with

poor clinical outcome in various malignancies. The aim of this study was to evaluate
the prognostic significance of serum CRP levels at diagnosis in patients with MF/
SS. This retrospective study included 76 patients with MF/SS. Stage was assigned
according to the ISCL/EORTC guidelines. The follow-up period was 24 months or

more. Disease course and response to treatment were determined using quantita-
tive scales. Wilcoxon’s rank test and multivariate regression analysis were used to

analyze the data. Increased CRP levels correlated significantly with advanced stages
(Wilcoxon’s test, P>0.0001). Furthermore, increased CRP levels were associated with
a lower treatment response rate (Wilcoxon’s test, P=0.0012). Multivariate regression
analysis showed that CRP is an independent predictor of advanced clinical stage at
diagnosis.The present data suggest that elevated CRP levels could serve as a useful
prognostic factor in MF/SS and may assist in guiding treatment choices.

Ključne riječi

mycosis fungoides, Sézary syndrome, C-reactive protein (CRP), prog- nostic factor

Hrčak ID:

299626

URI

https://hrcak.srce.hr/299626

Datum izdavanja:

14.9.2022.

Posjeta: 247 *