Pregledni rad
https://doi.org/10.26800/LV-145-supl1-6
Microbiome dysbiosis and asthma
Blaženka Kljaić Bukvić
; Odjel za pedijatriju, Opća bolnica „Dr Josip Benčević“, Slavonski Brod
Mario Blekić
Marija Pečnjak
Sažetak
The increase in the prevalence of allergic diseases in children is associated by the influence of the modern environment and lifestyle. The external environment with the microorganisms that surround us, modifies the internal environment, the microbiota of the intestines, skin and lungs. The microbiota of an organism is a reflection of environmental exposure. The imbalance, the dysbiosis of microorganisms in the lungs and in the gut, is in the complex interaction with the environment with the individual’s genetic susceptibility, modulates the metabolic and immune response, thus playing a strong role in the development of asthma during early childhood. It is the early development and the first years of life and growing up that are important in the development of asthma: due to the strong influence of the interplay between genes and the environment for shaping the immune response, due to susceptibility to repeated and severe infections that have late consequences, and due to the sensitive period of lung development that determines lung function in later life. childhood and adulthood. Epidemiological observations suggest a protective effect of growing up on farms on the onset of school-age asthma. The effect is modified by microorganisms and their metabolites, which activate metabolic and epigenetic changes during prenatal and early postnatal development, and through host-microbiome interaction, direct the directions of health and disease.
Ključne riječi
MICROBIOM; HOST-MICROBIOM INTERACTION; EARLY LIFE; ASTHMA
Hrčak ID:
300299
URI
Datum izdavanja:
17.4.2023.
Posjeta: 944 *