Professional paper

SERUM ACTIVITY OF ENZYMES AND BILIRUBIN IN PATIENTS WITH CIRRHOSIS AND LIVER CANCER

Nafija Serdarević ; 1 Institute for Clinical Biochemistry with Immunology, Clinical Center of the University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
Marina Ćurlin orcid.org/0009-0000-5615-2722 ; Faculty of Health Studies, University of Mostar
Monika Franković ; Faculty of Health Studies, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
Sabina Šegalo ; Faculty of Health Studies, University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
Nermina Klapuh-Bukvić ; Institute for Clinical Biochemistry with Immunology, Clinical Center of the University of Sarajevo, 71000 Sarajevo, Bosnia and Herzegovina
Ivana Vujica ; Hospital "Dr. Fr. Mato Nikolić", Laboratory, 72276 Nova Bila, Republic of Croatia

Abstract

Introduction: The most important biochemical reactions of the human organism take place in the liver, and
therefore it represents one of the most important organs for life. Parameters that play an important role in
the diagnosis and monitoring of patients are the enzymes ALT, AST, GGT, ALP, and bilirubin.
Objective: To evaluate the serum activity of enzymes and bilirubin in patients with liver cirrhosis and liver
cancer. Materials and methods: The study included 120 patients aged over 50 years. Among them, 40
patients had liver cirrhosis, 40 had cancer and liver metastases, and 40 patients were apparently healthy
(control group). The concentrations of AST, ALT, GGT, and ALP were determined on Abbott Architect
i2000sr biochemical analyzer and Dimension analyzer.
Results: The study showed that the mean values of the studied parameters were significantly higher in
subjects with liver cirrhosis and cancer with liver metastases than in the control group. A statistically
significant difference (p <0.05) was found in ALP and bilirubin concentrations between the studied groups.
In addition, the study revealed a statistically significant difference (p <0.05) in ALT, AST, and GGT activity
between subjects with cancer and the control group and subjects with cirrhosis and the control group.
Conclusions: The results confirm that the activities of enzymes ALT, AST, GGT, ALP, and bilirubin were
increased in subjects with cirrhosis and cancer compared to the control group.

Keywords

enzymes; bilirubin; liver cirrhosis; liver cancer

Hrčak ID:

304951

URI

https://hrcak.srce.hr/304951

Publication date:

31.5.2023.

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