Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2023.187

DETERMINING THE RISK OF CARDIOVASCULAR DISEASE IN PATIENTS DIAGNOSED WITH SCHIZOPHRENIA AND BIPOLAR AFFECTIVE DISORDER

Filiz İzci ; Sağlık Bilimleri University, Faculty of Medicine, Department of Psychiatry, Erenkoy mental and nervous diseases training and research hospital, Istanbul, Turkiye
Batuhan Ayık ; Sağlık Bilimleri University, Faculty of Medicine, Department of Psychiatry, Erenkoy mental and nervous diseases training and research hospital, Istanbul, Turkiye
Servet İzci ; Kosuyolu High Specialization Training and Research Hospital, Department of Cardiology, Istanbul, Turkiye
Çise Cemaller ; Sağlık Bilimleri University, Faculty of Medicine, Department of Psychiatry, Erenkoy mental and nervous diseases training and research hospital, Istanbul, Turkiye
Melike Erdemli ; Sağlık Bilimleri University, Faculty of Medicine, Department of Psychiatry, Erenkoy mental and nervous diseases training and research hospital, Istanbul, Turkiye

Sažetak

Background: In Schizophrenia (SCZ) and Bipolar Affective Disorder (BAD) patients using the Framingham Heart Risk Scoring (FHRS), we aimed to investigate the possible cardiac arrhythmia risk by calculating electrocardiogram (ECG) parameters (QT, QTc, Tpe, and TPE/QTc ratios), which are ventricular repolarization markers.
Subjects and methods: A total of 140 BAD and 253 SCZ patients were included in the study. Age, blood test results (fasting blood glucose, LDL-HDL-TC levels, hemogram values), blood pressure and heart rate, smoking status, antihypertensive drug use, and FHRS were calculated from the patient files, and sociodemographic information was recorded. In addition, ECG calculations were performed, and QT, QTc, TPe, TPe/QTc ratios and heart rate were measured.
Results: When we evaluated the cardiac risk indexes of SCZ and BAD patients, we detected that FHRS was higher in smokers, female patients, and those with other medical diseases such as diabetes mellitus (DM) (p<0.05). In addition, we found that QTc rates, markers of ventricular repolarization, were associated with FHRS, the number of antipsychotics used, patient age, disease duration, and the number of hospitalizations. TPe and QT rates were found to increase in parallel with FHRS. In addition, a positive correlation was found between QTc rates in females, patients with DM, and those using additional medical drugs. (p<0.05)
Conclusions: In BAD and SCZ patients, diabetes diagnosis, other medical drug use, a high Framingham heart score, the number of antipsychotics, the disease duration, the patient’s age, and an increased number of hospitalizations may increase the risk of cardiac arrhythmia. Therefore, possible cardiac risk should be considered in patients with chronic drug use, such as BAD and SCZ. Regulating the treatment and follow-up of this group of patients against possible cardiac risks will reduce cardiac mortality and morbidity.

Ključne riječi

Schizophrenia; Bipolar Affective Disorder; Framingham Heart Risk Score; Electrocardiogram

Hrčak ID:

306942

URI

https://hrcak.srce.hr/306942

Datum izdavanja:

17.7.2023.

Posjeta: 439 *