Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2023.210

MAY PPAR GAMMA BE SIGNIFICANT IN BIPOLAR DISORDER ONLY IN THE PRESENCE OF METABOLIC SYNDROME?

Burcu Kok Kendirlioglu ; MD, Asst. Prof., Department of Psychiatry, Maltepe University Faculty of Medicine, Istanbul, Turkey
Refik Cihnioglu ; MD, Department of Psychiatry, Kanuni Sultan Süleyman Research and Training Hospital , Istanbul, Turkey
Tevfik Kalelioglu ; MD, Research Associate, Department of Psychiatry, University of Virginia School of Medicine, USA
Pelin Unalan Ozpercin ; MD, Department of Psychiatry, Iskenderun State Hospital, Hatay, Turkey
Ozge Yuksel Oksuz ; MD, Department of Psychiatry, Sultangazi Haseki Research and Training Hospital, Istanbul
Sule Sozen ; MD, Department of Psychiatry, Balıklı Rum Hospital, Istanbul, Turkey
Nesrin Karamustafalioglu ; Prof. Dr., Department of Psychiatry, Bakırkoy Mental Health Research and Training Hospital, Istanbul, Turkey

Sažetak

Background: Peroxisome proliferator-activated receptor γ (PPARγ) has a key role in regulating both neurogenesis and various
metabolic processes, including adipogenesis and glucose homeostasis. In this study, it was aimed to compare the serum PPARγ levels
and metabolic syndrome (MetS) parametres of patients with Bipolar Disorder (BD) diagnosed manic-depressive-euthymic episodes
with those of healthy subjects.
Subjects and Methods: We included 121 male patients with BD type I, 44 in mania, 35 in depression and 42 in euthymic state,
and 41 healthy controls. Serum PPARγ levels, inflammation indicators (CRP, neutrophil, leukocyte, and albumin) and Mets parametres
were measured.
Results: There were no statistically significant differences between the groups in terms of PPARγ values. PPARγ serum level is
highest in the control group and then euthymic, manic and depressive episodes continue to decrease, respectively. However, there was a
significant difference between the depressive group with MetS and without MetS in terms of serum PPARγ levels. A statistically significant
correlation was found between PPARγ and the other serum markers such as low-density lipoprotein (p=0.022), HbA1c (p=0.002),
neutrophils levels (0.001), white blood cell (p=0.025), and clinical features such as age at first treatment (p=0.024), age at first episode
(p=0.039), and smoking (0.013).
Conclusions: We suggest that PPARγ may be a key factor in the BD depressive group with MetS. Not finding any relationship
between the PPARγ levels and the episode of BD may be related with the absence of MetS in the individuals. MetS parametres must also
be considered if PPARγ is to be evaluated in the future investigations.

Ključne riječi

bipolar disorder; metabolic syndrome; PPARγ; depressive episode; inflammation

Hrčak ID:

306944

URI

https://hrcak.srce.hr/306944

Datum izdavanja:

17.7.2023.

Posjeta: 548 *