Original scientific paper

https://doi.org/10.20471/acc.2023.62.01.23

Effect of Mammography Imaging Procedure on Serum Inflammatory and/or Tumor Marker Levels

Gulcin Sahingoz Erdal ; Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Aysegul Akdogan Gemici ; Department of Radiology, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Murat Cikot ; Department of General Surgery, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Sule Apikoglu Rabus ; Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Istanbul, Turkey
Nilgun Isiksacan ; Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Ercan Inci ; Department of Radiology, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey
Mehmet Hursitoglu orcid.org/0000-0002-9062-118X ; Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Training & Research Hospital, University of Health Sciences, Istanbul, Turkey; Department of Internal Medicine, Basaksehir Cam & Sakura Sehir Hospital, University of Health Sciences, Istanbul, Turkey

Abstract

Mammography is one of the gold standard screening tests for breast cancer. The
effects of mammography procedure on blood parameters are not known. This study aimed to investigate
whether the procedure-associated breast compression affects the widely and simultaneously
performed blood measurements of C-reactive protein (CRP), carcinoembryonic antigen (CEA), and
cancer antigen (CA) 15-3. According to breast ultrasound examination results, participants were divided
into 3 groups as follows: group 1 (participants with breast mass size ≥20.0 mm, n=48); group 2
(participants with breast mass size <20.0 mm, n=17); and group 3 (participants with no breast mass,
n=23). In groups 1 and 2, on the day of the mammographic imaging study, serum CRP, CEA, and CA
15-3 levels were measured before and after the imaging study. Participants in group 3 had their blood
parameters measured without mammography and/or any breast compression. Post-mammography
blood measurements displayed a significant increase in serum CRP levels, and a significant decrease
in serum CEA and CA 15-3 levels in group 1 (in comparison with the same day pre-mammography
blood sampling levels; p<0.05 all). Although pre-mammography serum CEA levels in group 1 participants
were significantly higher than those in group 2 and 3 participants, this significant elevation
became nonsignificant at post-mammography measurements (p<0.05 and p>0.05, respectively). On
the day of the mammographic imaging study, the optimal time of blood sampling for testing CRP,
CEA and CA 15-3 levels in persons with a breast mass is before, but not after the mammographic
imaging procedure. This issue requires additional detailed studies.

Keywords

Breast cancer; Blood tests; Breast compression; Mammography; C-reactive protein; Tumor markers

Hrčak ID:

307297

URI

https://hrcak.srce.hr/307297

Publication date:

1.4.2023.

Article data in other languages: croatian

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