Izvorni znanstveni članak
https://doi.org/10.20471/acc.2023.62.s2.7
Osteoprotegerin as an Early Sign of Chronic Kidney Disease-Mineral and Bone Disorder
Antun Gršković
orcid.org/0000-0002-4557-3879
; Department of Urology, Rijeka University Hospital Center, Rijeka, Croatia; Department of Urology, School of Medicine, University of Rijeka, Rijeka, Croatia
*
Tanja Ćelić
; Department of Human Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia
Josip Španjol
; Department of Urology, Rijeka University Hospital Center, Rijeka, Croatia; Department of Urology, School of Medicine, University of Rijeka, Rijeka, Croatia
Dean Markić
orcid.org/0000-0001-5696-0850
; Department of Urology, Rijeka University Hospital Center, Rijeka, Croatia; Department of Urology, School of Medicine, University of Rijeka, Rijeka, Croatia
Bosiljka Devčić
; Department of Nephrology, Dialysis and Kidney Transplantation, Rijeka University Hospital Center, Rijeka, Croatia
Dragica Bobinac
; Medical School, Juraj Dobrila University of Pula, Pula, Croatia
Sanjin Rački
orcid.org/0000-0002-3736-0929
; Department of Nephrology, Dialysis and Kidney Transplantation, Rijeka University Hospital Center, Rijeka, Croatia
* Dopisni autor.
Sažetak
Chronic kidney disease (CKD) is among the most significant health problems, with
the associated cardiovascular disease and bone metabolism disorders being the leading cause of morbidity
and mortality in these patients. The aim of the study was to determine markers of bone turnover
in patient sera (phosphates, calcium, alkaline phosphatase, parathyroid hormone and osteoprotegerin
(OPG)) in all stages of kidney failure including kidney transplant recipients. We also wanted to determine
whether dialysis vintage affects recovery of bone markers one year after transplantation. There were
164 study patients, whereas 30 healthy individuals served as a control group. Serum OPG progressively
increased with decline of the glomerular filtration rate. The highest OPG concentration was recorded
in dialysis group. We observed a statistically significant OPG increase in stage 2 CKD. In kidney
transplant group, there was positive correlation between OPG and dialysis vintage. We also found that
serum OPG was lower in patients treated with dialysis for less than 4 years prior to transplantation. We
confirmed that CKD-mineral and bone disorder began in stage 3 CKD with parathyroid hormone and
OPG elevation, and a statistically significant OPG increase in stage 2 CKD might be an early sign of
CKD-mineral and bone disorder. Dialysis vintage longer than 4 years is associated with more significant
disturbances in mineral and bone metabolism.
Ključne riječi
Renal dialysis; Renal insufficiency, chronic; Kidney transplantation; Osteoprotegerin; Chronic kidney disease–Mineral and bone disorder
Hrčak ID:
309041
URI
Datum izdavanja:
31.7.2023.
Posjeta: 915 *