Pregledni rad
https://doi.org/10.26800/LV-145-supl4-15
Traumatic brain injury associated coagulopathy
Petar Martinović
; Clinical department of anesthesiology, resuscitation and intensive medicine, University Hospital Dubrava, Zagreb, Croatia
Jasminka Peršec
Sažetak
Traumatic brain injury associated coagulopathy is a widely recognized risk factor for secondary brain damage and a powerful predictor related to outcome and prognosis. It is estimated that two thirds of patients with severe TBI will develop a coagulopathy. Pathophysiological pathway of TBI associated coagulopathy remains poorly defined. It includes combination of hypercoagulable and hypofibrinolytic states that result in persistent and delayed intracranial haemorrhage and systemic bleeding. The proposed mechanisms include release of tissue
factor, hyperfibrinolysis, disseminated intravascular coagulopathy, platelet disfunction and protein C activation. The goal of this review is to summarize the current knowledge regarding the mechanisms of traumatic brain injury associated coagulopathy and treatment options.67
Ključne riječi
COAGULOPATHY; TRAUMATIC BRAIN INJURY; TRAUMA; HAEMORRHAGE
Hrčak ID:
310278
URI
Datum izdavanja:
20.11.2023.
Posjeta: 242 *