Stručni rad
Antibiotic resistance – the leading medical problem at the beginning of the 21st century
Arjana Tambić Andrašević
; Klinika za infektivne bolesti «Dr. F. Mihaljević»
Sažetak
Development of antibiotic resistance jeopardizes not only our ability to treat classical infectious
diseases but it also threatens progress in many fields of medicine. Many invasive diagnostic and
therapeutic procedures have developed due to our ability to prevent and treat infective complications
with antibiotics. The World Health Organization has, therefore, stated the control of antibiotic
resistance to be one of its priorities and the European Union Council has put a request to all the
Member states to combat antibiotic resistance. The ability of bacteria to adapt to their environment is
huge and many resistance mechanisms have evolved so that there is no antibiotic to which
resistance has not emerged. The major clinical problems include: pneumococcal resistance to
penicillin and macrolides, mehticillin and multiple resistance in Staphylococcus aureus (MRSA),
enterobacteriaceae resistant to 3rd and 4th generation cephalosporins, carbapenem resistant
Pseudomonas aeruginosa and Acinetobacter baumanii. Antibiotic resistance control should be based
on local antibiotic resistance and antibiotic consumption surveillance, education of physicians and
patients on rational antibiotic use and infection control in the community (vaccination) and hospital
setting (nosocomial infection control). Rapid microbiological diagnostics contributes to the rational
approach to antimicrobial use by enabling accurate and timely diagnosis. In Croatia national antibiotic
resistance data are available since 1996, antibiotic consumption data expressed in defined daily doses
per thousand inhabitants daily (DDD/TID) since 2001 and in 2006 development of national
guidelines on antimicrobial therapy has been initiated.
Ključne riječi
Antibiotic resistance, resistance surveillance, control of the resistance spread
Hrčak ID:
297639
URI
Datum izdavanja:
7.4.2011.
Posjeta: 626 *