Review article
https://doi.org/10.21860/medflum2024_313680
Proton Pump Inhibitors: When, to Who and How Much? – Overview on Rational Pharmacotherapy
Andrej Belančić
orcid.org/0000-0001-7848-6600
; Klinički bolnički centar Rijeka, Odjel za kliničku farmakologiju, Rijeka, Hrvatska; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska
Andrea Kresović
; Sveučilište u Rijeci, Medicinski fakultet, Rijeka, Hrvatska; Klinički bolnički centar Rijeka, Klinika za internu medicinu, Zavod za gastroenterologiju, Rijeka, Hrvatska
Abstract
The prevalence of inadequate prescribing of proton pump inhibitors (PPIs) is in the range of 25-70%, which is certainly a significant problem when viewed from the perspective of rational pharmacotherapy/polypragmasia, pharmacoeconomics, but also pharmacovigilance. Continuous education, knowledge of clinical guidelines, better and clearer communication (direct and through medical records) between hospital specialists, family physicians and the patient himself, as well as regular reevaluation of the therapeutic need are of immense importance because they collectively result in prescribing the drug in the correct indication, through an adequate period and in the required dose. Therefore, the aim of this short review is to present justified indications for prescribing PPIs, discuss the most common misconceptions and dilemmas in clinical practice, evaluate the potential risks of their inadequate and long-term use, and lay the foundation for rational pharmacotherapy principles.
Keywords
Drug Prescriptions; Drug Therapy; Pharmacovigilance; Proton Pump Inhibitors
Hrčak ID:
313680
URI
Publication date:
1.3.2024.
Visits: 2.412 *