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Cardiologia Croatica, Vol. 19 No. 3-4, 2024.

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https://doi.org/10.15836/ccar2024.150

Ferritin in the prediction of cardiovascular risk in women - preliminary results

Katica Cvitkušić Lukenda orcid id orcid.org/0000-0001-6188-0708 ; General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia
Jelena Jakab orcid id orcid.org/0000-0002-5023-4409 ; Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health Osijek, Osijek, Croatia
Marijana Knežević Praveček orcid id orcid.org/0000-0002-8727-7357 ; General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia
Krešimir Gabaldo orcid id orcid.org/0000-0002-0116-5929 ; General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia
Anto Lukenda orcid id orcid.org/0000-0002-2275-1919 ; General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia
Vesna Ćosić orcid id orcid.org/0000-0003-1141-3102 ; Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health Osijek, Osijek, Croatia

Puni tekst: engleski pdf 165 Kb

str. 150-150

preuzimanja: 38

citiraj

Preuzmi JATS datoteku

Sažetak

Ključne riječi

cardiovascular risk; women; prevention; ferritin

Hrčak ID:

314417

URI

https://hrcak.srce.hr/314417

Datum izdavanja:

8.2.2024.

Posjeta: 88 *

Copyright statement: Croatian Cardiac Society

Copyright: 2023, Croatian Cardiac Society

Date received: 14 October 2023

Date accepted: 27 October 2023

Publication date: November 2023

Publication date: November 2023

Volume: 19

Issue: 3-4

Page: 150

Publisher ID: CC 2024 19_3-4_150

DOI: 10.15836/ccar2024.150

Article Information (continued)

Categories:

Subject: Extended Abstract

Categories:

Subject: Cardiovascular prevention and protection

KEYWORDS: :

KEYWORDS:

Keyword: cardiovascular risk

Keyword: women

Keyword: prevention

Keyword: ferritin

Ferritin in the prediction of cardiovascular risk in women - preliminary results

[https://orcid.org/0000-0001-6188-0708] Katica Cvitkušić Lukenda[1][2][*]

[https://orcid.org/0000-0002-5023-4409] Jelena Jakab[2]

[https://orcid.org/0000-0002-8727-7357] Marijana Knežević Praveček[1]

[https://orcid.org/0000-0002-0116-5929] Krešimir Gabaldo[1][2]

[https://orcid.org/0000-0002-2275-1919] Anto Lukenda[1]

[https://orcid.org/0000-0003-1141-3102] Vesna Ćosić[2]

 

[1] General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia

[2] Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health Osijek, Osijek, Croatia

Author notes:

Correspondence to: [*] ADDRESS FOR CORRESPONDENCE: Katica Cvitkušić Lukenda, Opća bolnica “Dr. Josip Benčević“, Andrije Štampara 42, HR-35000 Slavonski Brod, Croatia. / Phone: +385-98-556-576 / E-mail: kclukenda@gmail.com

Introduction: Over the past two decades, the prevalence of myocardial infarction (MI) has trended downward in both sexes in the United States and Europe, although this decline has been smaller in women. (1) According to the available literature, only two models predicting cardiovascular risk (CVD) in women included risk factors specific to women, which were reproductive risk factors. (2) Our previous research showed a significant association between ferritin, hsCRP, and systolic blood pressure in women working shift work. (3) In women, iron stores increase during menopause. We started a prospective study of CVD risk factors and CVD outcomes in women in Brod-Posavina County. Aim: To determine the association between ferritin level and menopause age as female-specific CVD risk factors in women and the influence of body mass index (BMI), non-HDL and hsCRP on cardiovascular risk in women.

Patients and Methods: Women aged 35 to 75 years, divided into two groups: women without coronary artery disease (CAD) and women with CAD (angiography, medical history of MI). The variables included in the evaluation are: age, BMI, menopause age and status, systolic blood pressure (SBP), non-HDL, ferritin, hsCRP, and smoking habits. Results are mean±SD. For the comparison of continuous variables, we used the Student t-test, whereas for the comparison of categorical variables, we used the Fisher exact test. P < 0.05 is considered statistically significant.

Results: We analyzed a total of 32 subjects matched by age. Women without CAD had a statistically significant lower BMI and higher SBP compared to women with CAD (Table 1). There was no statistically significant difference in menopause age, presence of menopause, smoking habits, and non-HDL. Ferritin and hsCRP levels were statistically significantly higher in the group of women with CAD.

TABLE 1 Differences between the two groups.
With CAD
(n=16)		Without CAD
(n=16)		P value*#
Age61.5±5.3760.38±4.270.52*
BMI31.15±5.7625.58±3.01<0.01*
SBP122.81±17.32131.53±11.75<0.05*
Menopause, n (%)15 (93.8)14 (87.5)1.00#
Menopause age48.73±4.8251.07±4.140.17*
non HDL4.23±1.254.6±0.70.31*
Ferritin96.12±63.7557.77±38.3<0.05*
hs CRP7.97±6.411.74±1.47<0.001*
Smoking habits, n (%)7 (43.8)7 (43.8)1.00#
BMI = body mass index; SBP = systolic blood pressure
*Student t test, #Fisher’s exact test

Conclusion: The preliminary results of our study show that women without CAD have statistically lower BMI, ferritin and hsCRP levels compared to women with CAD. There were no differences in menopause age and status, non-HDL or smoking habits. Further research is needed to improve women’s health.

LITERATURE

1 

Salari N, Morddarvanjoghi F, Abdolmaleki A, Rasoulpoor S, Khaleghi AA, Hezarkhani LA, et al. The global prevalence of myocardial infarction: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2023 April 22;23(1):206. https://doi.org/10.1186/s12872-023-03231-w PubMed: http://www.ncbi.nlm.nih.gov/pubmed/37087452

2 

Baart SJ, Dam V, Scheres LJJ, Damen JAAG, Spijker R, Schuit E, et al. CREW consortium. Cardiovascular risk prediction models for women in the general population: A systematic review. PLoS One. 2019 January 8;14(1):e0210329. https://doi.org/10.1371/journal.pone.0210329 PubMed: http://www.ncbi.nlm.nih.gov/pubmed/30620772

3 

Cvitkušić Lukenda K, Vučić D, Raguž A, Bitunjac I, Mišković D, Gabaldo K, et al. M. Relationship Between Serum Ferritin Levels, Arterial Hypertension and Shift Work in Women. A Cross-sectional Analysis. SEEMEDJ. 2021;5(2):27–37. https://doi.org/10.26332/seemedj.v5i2.210

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