Original scientific paper
Platelet-rich Plasma Stimulates Collagen Type I Synthesis in the Human Skin: A Placebo-controlled in vivo Study
Paweł Surowiak
orcid.org/0000-0002-4241-5197
; Department of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wrocław, Poland
Vladimir Tsepkolenko
; 3 Ukrainian Society of Aes- thetic Medicine, Odessa, Ukraine; 4 Ukrainian Institute of Plastic Surgery and Cosmetol- ogy VIRTUS, Odessa, Ukraine
Romuald Olszański
; Military Institute of the Health, Department of Maritime Medicine, Gdynia, Poland
Abstract
Platelet-rich plasma (PRP) is used in medicine as a source of au-
tologous growth factors in different indications. At present, PRP is applied
increasingly frequently in aesthetic medicine with the aim of skin revital-
ization. Until now, the mechanisms of PRP effects in healthy human skin
treated with aesthetic goals have not been identified in detail. This study
aimed to examine PRP effects on the synthesis of procollagen type I in hu-
man skin. This study was a prospective, single-center, single-dose, open-la-
bel, non-randomized controlled clinical study. The study was conducted on
a group of 10 volunteers in whom forearm skin was injected with PRP, while
the placebo control group received injections of 0.9% NaCl. Expression of
procollagen type I was examined after 21 days using immunohistochem-
istry. The study demonstrated that skin fragments subjected therapy using
PRP demonstrated a significantly higher expression of procollagen than that
which was observed in placebo controls. The study demonstrated that PRP
stimulated collagen expression in healthy human skin.
Keywords
platelet-rich plasma; skin, collagen; immunohistochemistry; aesthetic medicine
Hrčak ID:
316450
URI
Publication date:
15.12.2023.
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