Izvorni znanstveni članak
Upregulation of Anti-Desmocollin 3 Antibodies in Pemphigus Diseases: A Case-control Study
Marwah Adly Saleh
; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
Rana Mussa Said
; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
Laila Ahmed Rashed
; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt
Mona El-Kalioby
; Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt
Sažetak
Background: Pemphigus diseases are a subgroup of autoimmune bullous diseases
characterized by autoantibodies against desmogleins and occasionally desmocollins.
Desmocollin 3 is the main desmocollin isoform that contributes to cell adhesion in the
epidermis.
Objective: To evaluate the presence and level of anti-desmocollin 3 antibodies in
pemphigus diseases, and to investigate whether their presence is associated with a
specific type, presentation, or clinical pattern.
Methods: Forty patients with pemphigus diseases and forty healthy controls were enrolled. Medical history, clinical examination, and pemphigus disease area index (PDAI)
scoring were recorded for all patients. Serum samples were collected from both groups
for assessment of anti-desmocollin 3 antibody reactivity by ELISA.
Results: The presence of anti-desmocollin 3 antibodies was significant among patients
with pemphigus compared with controls (P=0.003). The level of anti-desmocollin 3
antibodies was also significantly higher in patients with pemphigus compared with
controls (P=0.01). There was no significant relationship between the presence of antidesmocollin 3 antibodies and any of the clinical presentations of pemphigus (type,
severity, duration, activity, presence of annular pattern, or site of affection – mucosal,
cutaneous, on the scalp, palmoplantar, or flexural).
Conclusion: Anti-desmocollin 3 antibodies are upregulated in pemphigus
diseases and can contribute to the pathogenesis of pemphigus. No specific
clinical type, presentation, or pattern was found to be associated with the
presence of anti-desmocollin 3 antibodies
Ključne riječi
cadherins; intraepidermal; atypical pemphigus; pemphigus vulgaris; superficial pemphigus
Hrčak ID:
316451
URI
Datum izdavanja:
15.12.2023.
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