Izvorni znanstveni članak

https://doi.org/10.5562/cca4052

Intriguing Properties of Three-factor Cross-reaction Series. Isoparametricity and Non-interaction Phenomena

Igor Shpan’ko ; Department of Chemistry, Biology and Biotechnology, Vasil’ Stus Donetsk National University, 21 600-Richchia Str., Vinnytsia 21021, Ukraine

Sažetak

This article summarizes the results of a systematic study by the method of cross-correlation analysis of the mutual influence of three variable factors (structure, temperature, and polarity of the medium) on the rates and activation parameters of nucleophilic substitution reactions at the benzoyl and benzyl electrophilic centers, as well as nucleophilic oxirane ring-opening reactions. Co-variation of three factors allowed to reveal the manifestation of various combinations of the second-order interaction of their effects, as well as the third-order interaction in the cross-reaction series. The conducted studies have shown that in the case of second-order interactions, cross-reaction series exhibit isoparametric properties, while third-order interactions manifest themselves in a specific way. This concerns the critical values of the parameters of the variable factors, at which the corresponding terms of three-parameter polylinear regressions disappear. Significant third-order interactions ensure the realization of the non-interaction phenomenon: at certain critical values, the corresponding second-order interaction coefficients become equal to zero, and after passing these critical values, the signs of these coefficients become opposite.

Ključne riječi

nucleophilic substitution; kinetics; activation parameters; compensation effect; cross-correlation analysis; isoparametricity; non-interaction phenomenon

Hrčak ID:

318130

URI

https://hrcak.srce.hr/318130

Datum izdavanja:

1.6.2024.

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