Izvorni znanstveni članak
https://doi.org/https://doi.org/10.5513/JCEA01/25.2.4198
Effect of bisphenol S and bisphenol A on morphometric and hormonal changes of thyroid gland and iodine concentration in urine of Wistar rats
Hana BERÁNKOVÁ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Roman KONEČNÝ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Jan TRÁVNÍČEK
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Michaela HOŘČIČKOVÁ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Eliška FRIEDBERGEROVÁ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Luboš ZÁBRANSKÝ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Bohumil SAK
; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
Nikola HOLUBOVÁ
; Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
Martin KVÁČ
; Department of Animal Husbandry Sciences, Faculty of Agriculture and Technology, University of South Bohemia in Ceske Budejovice, Studentska 1668, 370 05 Ceske Budejovice, Czech Republic
Sažetak
Bisphenol S (BPS) is the major substitute of the endocrine disruptor bisphenol A (BPA). Due to the presence of strong double bonds, BPS is more resistant to biodegradation and therefore more BPS remains in the environment. Numerous studies show that BPS disrupts the reproductive, nervous, and cardiovascular systems and could have an impact on thyroid hormones. The study aimed to analyze the effects of a 10-week exposition of BPS and BPA on lipid markers, morphometric parameters of the rat thyroid gland, the thyroid stimulating hormone (TSH) levels and the influence of BPS on urine iodine concentration. Male Wistar rats received BPS in sunflower oil daily by gavage. The control group (GI) received only the vehicle. The BPS experimental group two (GII) received 4 ug/kg/day, group three (GIII) received 50 ug/kg/day, and group four (GIV) received 100 mg BPS/kg/day. Group five (GV) received 100 mg BPA/kg/day. Groups four and five were made to compare the influence of high concentration between BPS and BPA. Results show the influence of BPS and BPA on body weight, triacylglycerols, cholesterol and total protein concentration. Morphometric changes in the size of thyroid gland follicles show a bigger influence of BPS than BPA. Results show also increasing in TSH concentrations in all groups with bisphenols up to physiology standards of Wistar rats (GI 3.14 ± 1.28 ng/ml, GII 5.12 ± 1.16 ng/ml, GIII 5.55 ± 2.39 ng/ml, GIV 5.56 ± 1.98 ng/ml, GV 4.47 ± 1.09 ng/ml) and influence of BPA and BPS on higher iodine concentrations in urine.
Ključne riječi
thyroid; iodine; follicles; triacylglycerols; cholesterol; protein; TSH
Hrčak ID:
318552
URI
Datum izdavanja:
28.6.2024.
Posjeta: 23 *