Izvorni znanstveni članak

https://doi.org/10.20471/acc.2023.62.04.7

Evaluation of the Relationship between Paraoxonase-1 Enzyme Activity, Affected Volume, and Stroke Onset in Acute Ischemic Stroke Patients

Serhat Atmaca ; Emergency Department, Turkey University of Health Sciences, Bursa, Turkey
Suna Eraybar orcid.org/0000-0003-4306-9262 ; Emergency Department, Turkey University of Health Sciences, Bursa, Turkey *
Yasemin Nennicioglu ; Emergency Service, Nusaybin Government Hospital, Mardin, Turkey
Melih Yuksel orcid.org/0000-0002-0793-3693 ; Emergency Department, Turkey University of Health Sciences, Bursa, Turkey
Halil Kaya orcid.org/0000-0003-2005-6100 ; Emergency Department, Turkey University of Health Sciences, Bursa, Turkey

* Dopisni autor.

Sažetak

Acute ischemic stroke has an important place among emergency department admissions.
After a rapid diagnosis of the patient admitted with a preliminary diagnosis of stroke, the necessary
examination and first intervention should be performed, then diagnostic evaluation should be made.
The aim of this study was to investigate whether paraoxonase-1 (PON-1) enzyme activity, measured in
patients whose stroke onset is known, is a diagnostic biomarker for stroke by evaluating the relationship
between stroke diagnosis, ischemic area volume, and stroke onset. The study included 100 patients over
age 18 admitted to the emergency department with acute stroke symptoms, with known stroke onset and
diagnosed as acute occlusive cerebrovascular disease within 24 hours, and 100 healthy control subjects.
After initial evaluation, computed tomography of the brain and magnetic resonance imaging, PON-1
activity was measured by colorimetric method in patient serum. Comparison of PON-1 levels between
the two groups yielded a statistically significant difference. There was a significant decrease in serum
PON-1 values in patient group as compared with control group (p<0.001). According to these results, no
significant relationship was found between the affected ischemic area of the brain, PON-1, and ischemic
volume values. The possible relationship between PON-1 values and stroke onset was compared and no
statistically significant difference was found (p=0.311). The relationship between PON-1 enzyme activity
and diagnosis of acute ischemic stroke was found to be significant. PON-1 was found to be lower in
stroke patients but no correlation was found with ischemic area volume.

Ključne riječi

Emergency department; Stroke; Paraoxonase-1 enzyme activity; Stroke onset; Ischemic area volume

Hrčak ID:

320280

URI

https://hrcak.srce.hr/320280

Datum izdavanja:

31.12.2023.

Podaci na drugim jezicima: hrvatski

Posjeta: 284 *