Pregledni rad

The role of Toll-like receptors in the etiopathogenesis and treatment of schizophrenia: a literature review

Maristela Šakić ; Specijalna bolnica za psihijatriju i palijativnu skrb "Sv. Rafael", Šumetica, Hrvatska
Vanja Đuričić ; Nacionalna memorijalna bolnica "Dr. Juraj Njavro" Vukovar, Odjel psihijatrije, Vukovar, Hrvatska
Antonija Mišković ; Opća bolnica "Dr. Josip Benčević" Slavonski Brod, Odjel otorinolaringologije, Slavonski Brod, Hrvatska
Sara Đuričić ; Medicinski fakultet Osijek, Osijek, Hrvatska
Melita Jukić ; Nacionalna memorijalna bolnica "Dr. Juraj Njavro" Vukovar, Odjel psihijatrije, Vukovar, Hrvatska

Sažetak

In this review paper, we present current theories about the inflammatory etiopathogenesis of
schizophrenia. We mentioned the biopsychosocial etiological model of the disease and stressed the
importance of neuroinflammation and neurodegeneration in its biological basis.
We searched the literature about innate immunity, Toll-like receptors, inflammation, and
neurodegeneration, and we summarized their role in the etiopathogenetic mechanisms of schizophrenia.
We also found studies on available antipsychotics that can regulate the expression of Toll-like receptors
and modulate innate inflammatory mechanisms. Despite the effective properties of antipsychotics in
reducing psychotic symptoms, their role in inflammatory mechanisms remains imprecise and underresearched.
More specific information about how antipsychotics affect neuroinflammation could lead to the
development of a wider range of possible drugs that could keep inflammatory processes working properly
and improve mental abilities and, ultimately, the quality of life.

Ključne riječi

anti-psychotics; immunity; inflammation; neurodegeneration; schizophrenia

Hrčak ID:

320586

URI

https://hrcak.srce.hr/320586

Datum izdavanja:

6.9.2024.

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