Pregledni rad
https://doi.org/10.21857/y26kecg5p9
Association of Parkinson’s Disease and Exposure to Aluminium and Other Heavy Metals
Lucija Vrbanc
; School of Medicine, University of Zagreb, Zagreb, Croatia
Ema Vrdoljak
; School of Medicine, University of Zagreb, Zagreb, Croatia
Filip Đerke
; Department of Neurology, University Hospital Dubrava, Zagreb, Croatia
*
* Dopisni autor.
Sažetak
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, accompanied by motor symptoms such as bradykinesia, rigidity, and tremors. While its etiology is multifactorial, recent research highlights the role of heavy metal exposure, including aluminium, mercury, manganese, and lead, in the pathogenesis of PD. These metals, through mechanisms such as oxidative stress, mitochondrial dysfunction, and disruption of the blood-brain barrier, exacerbate neurotoxicity and neuronal degeneration.Oxidative stress emerges as a pivotal factor in PD, driven by an imbalance between reactive oxygen species (ROS) and antioxidants. Heavy metals amplify this imbalance, inducing cellular damage that parallels natural aging processes. Aluminium, in particular, has garnered attention due to its ubiquitous presence in the environment and significant neurotoxic potential. Exposure occurs through contaminated water, food, occupational hazards, and consumer products. Aluminium disrupts neuronal function by enhancing oxidative stress, impairing calcium signaling, and inhibiting DNA synthesis. It accumulates in brain regions such as the hippocampus and cortex, promoting neuroinflammation and accelerating neurodegeneration. Epidemiological and experimental studies underscore the synergistic toxicity of metal mixtures, suggesting a compounded risk in individuals exposed to multiple sources. Chelation therapy shows promise in mitigating heavy metal-induced neurotoxicity but faces challenges in reversing chronic exposure damage. Investigations into environmental exposure reduction strategies, such as consuming silicon-rich mineral water to limit aluminium absorption, hold preventive potential. Understanding the intricate relationship between heavy metals and PD is crucial for developing targeted interventions. Further research is needed to elucidate specific molecular pathways and refine therapeutic approaches to mitigate environmental risk factors.
Ključne riječi
Parkinson’s disease; Heavy metals; Oxidative stress; Neurodegeneration; Environmental exposure
Hrčak ID:
326025
URI
Datum izdavanja:
20.12.2024.
Posjeta: 0 *