Original scientific paper
https://doi.org/10.3325/cmj.2022.63.515
Novel micro-MRI approach for subchondral trabecular bone analysis in patients with hip osteoarthritis is comparable to micro-CT approach
Tea Duvančić
; University of Zagreb School of Medicine, Zagreb, Croatia
Siniša Škokić
; Laboratory for Regenerative Neuroscience – GlowLab, Croatian Institute for Brain Research, University of Zagreb School of Medicine, Zagreb, Croatia
Igor Erjavec
; University of Zagreb School of Medicine, Zagreb, Croatia
Mihovil Plečko
; University Hospital Center Zagreb, Zagreb, Croatia
Ivan Bohaček
; Department of Orthopedic Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
Srećko Gajović
; University of Zagreb School of Medicine, Zagreb, Croatia
Domagoj Delimar
; Department of Orthopedic Surgery, University of Zagreb School of Medicine, University Hospital Center Zagreb, Zagreb, Croatia
*
* Corresponding author.
Abstract
Aim To test the agreement between a newly developed
micro-magnetic resonance imaging (MRI) analysis of the
subchondral bone and the micro-computed tomography
(CT) approach.
Methods Samples obtained from 10 patients with osteoarthritis undergoing total hip arthroplasty were scanned
with a 7.0 T micro-MRI. Proton density-weighted images
and proton density-weighted images with fat suppression
were obtained. The results were validated with a micro-CT
device. Micro-MRI and micro-CT scans of the same sample
were aligned, and regions of interest were delineated on
equal areas of the sample. Bone volume fraction was calculated by using in-house plugins. The agreement between
the methods was tested with Bland-Altman analysis.
Results The agreement between the methods was good,
with average difference of 2.167%. The differences between the methods were not significant (P=0.272, t test).
Conclusion The novel micro-MRI approach could be used
for subchondral bone analysis. With further optimization
for clinical MRI machines, the approach can be also used in
the diagnostics of hip osteoarthritis.
Keywords
Hrčak ID:
331073
URI
Publication date:
15.12.2022.
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