Original scientific paper
https://doi.org/10.3325/cmj.2022.63.544
Cognitive function and cardiorespiratory fitness affect gait speed in type-2 diabetic patients without neuropathy
Gulin Findikoglu
; Department of Physical Medicine and Rehabilitation, Pamukkale University, Denizli, Turkey
*
Abdurrahim Altinkapak
; Department of Physical Medicine and Rehabilitation, Pamukkale University, Denizli, Turkey
Hakan Alkan
; Department of Physical Medicine and Rehabilitation, Pamukkale University, Denizli, Turkey
Necmettin Yildiz
; Department of Physical Medicine and Rehabilitation, Pamukkale University, Denizli, Turkey
Hande Senol
; Department of Biostatistics, Pamukkale University, Denizli, Turkey
Fusun Ardic
; Department of Physical Medicine and Rehabilitation, Pamukkale University, Denizli, Turkey
* Corresponding author.
Abstract
Aim To identify physical, cognitive, and metabolic factors
affecting gait speed in patients with type-2 diabetes mellitus (T2DM) without neuropathy.
Methods This cross-sectional study enrolled 71 diabetic
patients without neuropathy (mean age 55.87±7.74 years,
85.9% women). Neuropathy status was assessed with
Douleur Neuropathique 4. We used a cut-off point for gait
speed of 1 m/s to classify the participants into two groups:
slow walkers (SW) and average and brisk walkers (ABW).
The groups were compared in terms of age, sex, body mass
index (BMI), hemoglobin A1c (HbA1c), fasting glucose, systolic blood pressure, maximal aerobic capacity (VO2 max),
percentage of muscle mass, percentage of lower extremity muscle mass, Mini-Mental State Examination (MMSE)
score, and years of education.
Results Compared with the ABW group, the SW group
had significantly lower VO2
max (14.49±2.95 vs 16.25±2.94
mL/kg/min) and MMSE score (25.01±3.21 vs 27.35±1.97),
fewer years of education, and these patients were more
frequently women (P<0.05). In the multivariate regression
models, the combination of VO2 max, sex, and MMSE score
explained only 23.5% of gait speed (P<0.001). MMSE score
and VO2 max independently determined gait speed after
adjustment for age, BMI, HbA1c, fasting glucose, systolic
blood pressure, percent of muscle mass, percent of lower
extremity muscle mass, and years of education.
Conclusion In diabetic patients without neuropathy, physical impairment and disability could be prevented by an improvement in aerobic capacity and cognitiv
Keywords
Hrčak ID:
331076
URI
Publication date:
15.12.2022.
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