Original scientific paper
https://doi.org/10.3325/cmj.2022.63.578
The association of bone mineral density Z-score with the early postoperative remission and characteristics of bone mineral loss in patients with Cushing’s disease: a retrospective study
Emre Gezer
; Division of Endocrinology and Metabolism, Darica Farabi Training and Research Hospital, Kocaeli, Turkey
*
Zeynep Cantürk
; Department of Endocrinology, Kocaeli University, Kocaeli, Turkey
Alev Selek
; Department of Endocrinology, Kocaeli University, Kocaeli, Turkey
Berrin Çetinarslan
; Department of Endocrinology, Kocaeli University, Kocaeli, Turkey
Mehmet Sözen
; Department of Endocrinology, Kocaeli University, Kocaeli, Turkey
Özlem Elen
; Department of Internal Medicine, Kocaeli University, Kocaeli, Turkey
İhsan Anık
; Department of Neurosurgery, Kocaeli University, Kocaeli, Turkey
Savaş Ceylan
; Department of Neurosurgery, Kocaeli University, Kocaeli, Turkey
* Corresponding author.
Abstract
Aim To investigate the association of bone mineral density
(BMD) Z-scores with early-postoperative remission rate and
clinical parameters in patients with Cushing’s disease (CD).
Methods We retrospectively evaluated the records of patients diagnosed with CD. After the exclusion of 230 patients, 87 CD patients were finally enrolled. BMD was determined by dual-energy x-ray absorptiometry (DXA) at the
lumbar spine 1-4 (L1–4) and left femur. Early-postoperative
remission was defined as a morning cortisol concentration
on the first day after surgery of less than 5 μg/dL. The diagnosis of BMD “below the expected range for age” was defined as a Z-score≤-2.00 standard deviations.
Results DXA results were not significantly associated with
early postoperative remission. They also did not significantly differ between eugonadal and menopausal groups.
Preoperative morning cortisol significantly negatively but
weakly correlated with Z-score of the total femur, while
preoperative adrenocorticotropic hormone/cortisol ratio
positively but weakly correlated with DXA results of L1-4.
Conclusion The severity of bone loss was not significantly
related to the failure of transsphenoidal surgery for Cushing’s disease.
Keywords
Hrčak ID:
331080
URI
Publication date:
15.12.2022.
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