Original scientific paper
https://doi.org/10.3325/cmj.2023.64.21
Anti-obesity effect of collagen peptides obtained from Diplulmaris antarctica, a jellyfish of the Antarctic region
Nataliia Raksha
; Department of Biochemistry, Educational and Scientific Center
*
Tetiana Halenova
; Department of Biochemistry, Educational and Scientific Center
Tetiana Vovk
; Department of Biochemistry, Educational and Scientific Center
Olexandra Kostyuk
; Department of Biochemistry, Educational and Scientific Center
Tatyana Synelnyk
; Department of Biochemistry, Educational and Scientific Center
Tatyana Andriichuk
; Department of Biochemistry, Educational and Scientific Center
Tetiana Maievska
; Ukrainian Fishing Industry Cluster of Innovations, Kyiv, Ukraine
Olexiy Savchuk
; Department of Biochemistry, Educational and Scientific Center
Ludmila Ostapchenko
; Department of Biochemistry, Educational and Scientific Center
* Corresponding author.
Abstract
Aim To investigate the ability of collagen peptides derived
from a jellyfish of the Antarctic region (Diplulmaris antarctica) to prevent the development of obesity in rats fed a
high-calorie diet.
Methods Collagen peptides were produced by pepsin hydrolysis of jellyfish-derived collagen. The purity of collagen
and collagen peptides was confirmed by SDS-polyacrylamide gel electrophoresis. Rats were fed a high-calorie diet
for ten weeks and were simultaneously orally administered
collagen peptides (1 g per 1 kg of body weight every other
day) starting from the fourth week. Body mass index (BMI),
body weight gain, selected nutritional parameters, the key
parameters associated with insulin resistance, and the level
of oxidative stress markers were assessed.
Results Compared with untreated obese rats, rats treated with hydrolyzed jellyfish collagen peptides had a decreased body weight gain and body mass index. They also
had a decreased level of fasting blood glucose, glycated hemoglobin, insulin, lipid peroxidation products (conjugated
dienes, Schiff bases), and oxidatively modified proteins, as
well as a restored activity of superoxide dismutase.
Conclusion Collagen peptides obtained from Diplulmaris
antarctica can be used to prevent and treat obesity caused
by a high-calorie diet and pathologies associated with increased oxidative stress. Given the obtained results and
the abundance of Diplulmaris antarctica in the Antarctic
region, this species can be considered a sustainable source
of collagen and its derivatives.
Keywords
Hrčak ID:
331246
URI
Publication date:
1.3.2023.
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