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Croatian Medical Journal, Vol. 64 No. 1, 2023.

Original scientific paper

https://doi.org/10.3325/cmj.2023.64.29

Immunohistochemical expression of apolipoprotein B and 4-hydroxynonenal proteins in colorectal carcinoma patients: a retrospective study

Phei Ying Ng ; Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Siti Norasikin Mohd Nafi ; Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia *
Nur Asyilla Che Jalil ; Department of Pathology, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Yee Cheng Kueh ; Biostatistics and Research Methodology Unit, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Yeong Yeh Lee ; Biostatistics and Research Methodology Unit, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia
Anani Aila Mat Zin ; Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

* Corresponding author.

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Abstract

Aim To assess the association of the expression of apolipoprotein B (apoB) and 4-hydroxynonenal (4HNE) with the
clinicopathological data of patients with colorectal cancer
(CRC).
Methods We obtained 80 CRC histopathological specimens sent to the Pathology Laboratory of Hospital Universiti Sains Malaysia from 2015 to 2019. Data on demographic factors, body mass index (BMI), and clinicopathological
characteristics were also collected. Formalin-fixed paraffinembedded tissues were stained by using an optimized immunohistochemical protocol.
Results Patients were mostly older than 50 years, male,
Malay, and overweight or obese. A high apoB expression
was observed in 87.5% CRC samples (70/80), while a high
4HNE expression was observed in only 17.5% (14/80) of
CRCs. The expression of apoB was significantly associated
with the sigmoid and rectosigmoid tumor sites (p =0.001)
and tumor size 3-5 cm (p =0.005). 4HNE expression was
significantly associated with tumor size 3-5 cm (p =0.045).
Other variables were not significantly associated with the
expression of either marker.
Conclusion ApoB and 4HNE proteins may play a role in
promoting CRC carcinogenesis.

Keywords

Hrčak ID:

331249

URI

https://hrcak.srce.hr/331249

Publication date:

1.3.2023.

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