Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2023.64.67
Association between serological indicators of past contacts with Herpesviridae and a slower resolution of chronic spontaneous urticaria in children
Anamarija Čavčić
; Department of Pediatrics, University Hospital Center Zagreb, Zagreb, Croatia
*
Oktavija Đaković Rode
; Division of Medical Virology, Department of Microbiology, Dr. Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
Vladimir Trkulja
; Department of Pharmacology, University of Zagreb School of Medicine, Zagreb, Croatia
* Dopisni autor.
Sažetak
Aim To evaluate the relationship between serological indicators of Herpesviridae infection and evolution of symptoms in children with chronic spontaneous urticaria (CSU).
Methods In this observational study, consecutive children
with CSU underwent, at presentation, clinical and laboratory work-up, autologous serum skin test (ASST) to identify
autoimmune urticaria (CAU), disease severity assessment
(urticaria activity score 7, UAS7), serological diagnostics
for Epstein-Barr virus (EBV), cytomegalovirus (CMV), human herpes virus-6 (HHV-6), and parvovirus B19, as well as
for Mycoplasma pneumoniae and Chlamydia pneumoniae.
Children were re-assessed at 1, 6, and 12 months after the
commencement of antihistamine/antileukotriene treatment.
Results None of the 56 included children had an acute
CMV/EBV or HHV-6 infection, but 17 (30.3%) had IgG antibodies against CMV, EBV, or HHV-6 (five were also seropositive for parvovirus B19); 24 (42.8%) suffered from CAU;
and 9 (16.1%) were seropositive for Mycoplasma/Chlamydia
pneumoniae. The initial symptom severity was moderateto-severe (UAS7 quartiles 18-32) and comparable between
Herpesviridae-seropositive and Herpesviridae-seronegative
patients. At 1, 6, and 12 months, UAS7 was consistently higher in seropositive children. In a multivariable analysis (adjusted for age, baseline UAS7, ASST, mean platelet volume,
and other serology), Herpesviridae seropositivity was associated with higher UAS scores: mean difference 4.2 score
points (95% confidence interval 0.5-7.9; Bayes estimate 4.2,
95% credible interval 1.2-7.3) in a mixed model for repeated
measures. This estimate was comparable between children
with positive (CAU) and negative (CSU) ASST.
Conclusion A history of CMV/EBV/HHV-6 infection might
contribute to a slower-resolving CSU in children.
Ključne riječi
Hrčak ID:
331515
URI
Datum izdavanja:
31.5.2023.
Posjeta: 472 *